Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells

Cathepsin K is a protease known to be involved in not only bone remodeling and resorption, but also articular cartilage degradation that leads to osteoarthritis (OA). Hyaluronan (HA) plays a pivotal role in maintaining homeostasis within articular chondrocytes. Intra-articular supplementation of hig...

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Detalles Bibliográficos
Autores principales: Suzuki, Mochihito, Takahashi, Nobunori, Sobue, Yasumori, Ohashi, Yoshifumi, Kishimoto, Kenji, Hattori, Kyosuke, Ishiguro, Naoki, Kojima, Toshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959248/
https://www.ncbi.nlm.nih.gov/pubmed/31937805
http://dx.doi.org/10.1038/s41598-019-57073-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959248/
https://www.ncbi.nlm.nih.gov/pubmed/31937805
http://dx.doi.org/10.1038/s41598-019-57073-8

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