Efficient tissue-type specific expression of target genes in a tetracycline-controlled manner from the ubiquitously active Eef1a1 locus

Using an efficient gene targeting approach, we developed a novel mouse line that expresses the tetracycline-controlled transactivator (tTA) from the constitutively active Eef1a1 locus in a Cre recombinase-inducible manner. The temporally and spatially controlled expression of the EF1-LSL-tTA knockin...

Descripción completa

Detalles Bibliográficos
Autores principales: Sakamoto, Kazuhito, Rädler, Patrick D., Wehde, Barbara L., Triplett, Aleata A., Shrestha, Hridaya, Ferraiuolo, Rosa-Maria, Amari, Foued, Coppola, Vincenzo, Klinakis, Apostolos, Efstratiadis, Argiris, Wagner, Kay-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959320/
https://www.ncbi.nlm.nih.gov/pubmed/31937792
http://dx.doi.org/10.1038/s41598-019-57052-z

Ejemplares similares

Ejemplares similares