Cargando…

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains superficial. Here, using single cell transcriptomics, we identify a specific location-associated composition and transcriptome of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schafflick, David, Xu, Chenling A., Hartlehnert, Maike, Cole, Michael, Schulte-Mecklenbeck, Andreas, Lautwein, Tobias, Wolbert, Jolien, Heming, Michael, Meuth, Sven G., Kuhlmann, Tanja, Gross, Catharina C., Wiendl, Heinz, Yosef, Nir, Meyer zu Horste, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959356/ https://www.ncbi.nlm.nih.gov/pubmed/31937773 http://dx.doi.org/10.1038/s41467-019-14118-w

Ejemplares similares

Immune Cell Profiling of the Cerebrospinal Fluid Provides Pathogenetic Insights Into Inflammatory Neuropathies
por: Heming, Michael, et al.
Publicado: (2019)

Cerebrospinal Fluid Concentrations of Neuronal Proteins Are Reduced in Primary Angiitis of the Central Nervous System
por: Ruland, Tillmann, et al.
Publicado: (2018)

Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses
por: Räuber, Saskia, et al.
Publicado: (2021)

Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
por: Kasper, Maren, et al.
Publicado: (2021)

Supporting the differential diagnosis of connective tissue diseases with neurological involvement by blood and cerebrospinal fluid flow cytometry
por: Heming, Michael, et al.
Publicado: (2023)

Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid
por: Heming, Michael, et al.
Publicado: (2021)

High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses
por: Heming, Michael, et al.
Publicado: (2022)

Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease
por: Schröder, Jens B., et al.
Publicado: (2018)

Novel pathomechanisms in inflammatory neuropathies
por: Schafflick, David, et al.
Publicado: (2017)

Bcl6 controls meningeal Th17–B cell interaction in murine neuroinflammation
por: Hartlehnert, Maike, et al.
Publicado: (2021)

Contactin-associated protein 2 autoantibodies can be associated with multifocal motor-like neuropathy: a case report
por: Müller-Miny, Louisa, et al.
Publicado: (2023)

Stroke induces disease-specific myeloid cells in the brain parenchyma and pia
por: Beuker, Carolin, et al.
Publicado: (2022)

Integrated single-cell transcriptomics of cerebrospinal fluid cells in treatment-naïve multiple sclerosis
por: Straeten, Frederike, et al.
Publicado: (2022)

Intratumor heterogeneity and T cell exhaustion in primary CNS lymphoma
por: Heming, Michael, et al.
Publicado: (2022)

Neurocognitive decline in HIV patients is associated with ongoing T-cell activation in the cerebrospinal fluid
por: Grauer, Oliver M, et al.
Publicado: (2015)

Pretreatment anti-thyroid autoantibodies indicate increased risk for thyroid autoimmunity secondary to alemtuzumab: A prospective cohort study
por: Ruck, Tobias, et al.
Publicado: (2019)

Enhanced pathogenicity of Th17 cells due to natalizumab treatment: Implications for MS disease rebound
por: Janoschka, Claudia, et al.
Publicado: (2022)

Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity
por: Wolbert, Jolien, et al.
Publicado: (2020)

Intravenous methadone causes acute toxic and delayed inflammatory encephalopathy with persistent neurocognitive impairments
por: Repple, Jonathan, et al.
Publicado: (2021)

Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II
por: Hartlehnert, Maike, et al.
Publicado: (2017)

Generation of a Model to Predict Differentiation and Migration of Lymphocyte Subsets under Homeostatic and CNS Autoinflammatory Conditions
por: Gross, Catharina C., et al.
Publicado: (2020)

Immune Cell Profiling During Switching from Natalizumab to Fingolimod Reveals Differential Effects on Systemic Immune-Regulatory Networks and on Trafficking of Non-T Cell Populations into the Cerebrospinal Fluid—Results from the ToFingo Successor Study
por: Lohmann, Lisa, et al.
Publicado: (2018)

Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity
por: Ruck, Tobias, et al.
Publicado: (2022)

Deterministic programming of human pluripotent stem cells into microglia facilitates studying their role in health and disease
por: Speicher, Anna M., et al.
Publicado: (2022)

Cytotoxic CD8(+) T cells and CD138(+) plasma cells prevail in cerebrospinal fluid in non-paraneoplastic cerebellar ataxia with contactin-associated protein-2 antibodies
por: Melzer, Nico, et al.
Publicado: (2012)

Onconeural antigen spreading in paraneoplastic neurological disease due to small cell lung cancer
por: Dik, Andre, et al.
Publicado: (2018)

The Innate Immune Response Characterizes Posterior Reversible Encephalopathy Syndrome
por: Nelke, Christopher, et al.
Publicado: (2021)

Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis
por: Gross, Catharina C., et al.
Publicado: (2015)

A fatal case of daclizumab-induced liver failure in a patient with MS
por: Stettner, Mark, et al.
Publicado: (2019)

Amyotrophic lateral sclerosis patients show increased peripheral and intrathecal T-cell activation
por: Rolfes, Leoni, et al.
Publicado: (2021)

Classification of neurological diseases using multi-dimensional CSF analysis
por: Gross, Catharina C, et al.
Publicado: (2021)

Treating refractory post-herpetic anti-N-methyl-d-aspartate receptor encephalitis with rituximab
por: Strippel, Christine, et al.
Publicado: (2017)

Fulminant MS Reactivation Following Combined Fingolimod Cessation and Yellow Fever Vaccination
por: Rolfes, Leoni, et al.
Publicado: (2019)

Cerebrospinal fluid analysis in 108 patients with progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2020)

High anti-JCPyV serum titers coincide with high CSF cell counts in RRMS patients
por: Schneider-Hohendorf, Tilman, et al.
Publicado: (2020)

Regulatory Functions of Natural Killer Cells in Multiple Sclerosis
por: Gross, Catharina C., et al.
Publicado: (2016)

Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia
por: Trossbach, Svenja V., et al.
Publicado: (2019)

Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells
por: Ruck, Tobias, et al.
Publicado: (2018)

Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses
por: Pfeuffer, Steffen, et al.
Publicado: (2022)

Immunophenotyping of cerebrospinal fluid cells by Chipcytometry
por: Hümmert, Martin W., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5vdt5k6hv554gc9dfe7aaoiqs4