Haspin-dependent and independent effects of the kinase inhibitor 5-Iodotubercidin on self-renewal and differentiation

The kinase Haspin phosphorylates histone H3 at threonine-3 (H3T3ph), creating a docking site for the Chromosomal Passenger Complex (CPC). CPC plays a pivotal role in preventing chromosome misalignment. Here, we have examined the effects of 5-Iodotubercidin (5-ITu), a commonly used Haspin inhibitor,...

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Detalles Bibliográficos
Autores principales: Karanika, Eleftheria, Soupsana, Katerina, Christogianni, Anastasia, Stellas, Dimitris, Klinakis, Apostolos, Politou, Anastasia S., Georgatos, Spyros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959359/
https://www.ncbi.nlm.nih.gov/pubmed/31937797
http://dx.doi.org/10.1038/s41598-019-54350-4

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