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TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

IL-2 is a pleiotropic cytokine that plays an essential role in the survival, expansion, and function of CD8 T cells, regulatory T cells (Tregs), and natural killer (NK) cells. Previous studies showed that binding IL-2 with an anti-IL-2 monoclonal antibody (mAb) with a particular specificity could bl...

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Detalles Bibliográficos
Autores principales:	Lee, Jun-Young, Lee, Eunjin, Hong, Sung-Wook, Kim, Daeun, Eunju, O., Sprent, Jonathan, Im, Sin-Hyeog, Lee, You Jeong, Surh, Charles D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959431/ https://www.ncbi.nlm.nih.gov/pubmed/32002288 http://dx.doi.org/10.1080/2162402X.2019.1681869

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