ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer

Inhibitor of apoptosis protein (IAP) antagonists have shown activity in preclinical models of head and neck squamous cell carcinoma (HNSCC), and work across several cancer types has demonstrated diverse immune stimulatory effects including enhancement of T cell, NK cell, and dendritic cell function....

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Detalles Bibliográficos
Autores principales: Ye, Wenda, Gunti, Sreenivasulu, Allen, Clint T., Hong, Youji, Clavijo, Paul E., Van Waes, Carter, Schmitt, Nicole C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959437/
https://www.ncbi.nlm.nih.gov/pubmed/32002309
http://dx.doi.org/10.1080/2162402X.2019.1710398

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