Destroy, what destroys you

New evidence indicates the importance of CD137 for controlling Epstein-Barr virus (EBV) infections. (1) Mutations in CD137 predispose to EBV-associated diseases. (2) EBV induces ectopic CD137 expression, thereby activating a negative feed-back regulation and reducing T cell costimulation. These find...

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Detalles Bibliográficos
Autores principales: Luu, Khang, Nickles, Emily, Schwarz, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Point-of-View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959443/
https://www.ncbi.nlm.nih.gov/pubmed/32002301
http://dx.doi.org/10.1080/2162402X.2019.1685301
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author Luu, Khang
Nickles, Emily
Schwarz, Herbert
author_facet Luu, Khang
Nickles, Emily
Schwarz, Herbert
author_sort Luu, Khang
collection PubMed
description New evidence indicates the importance of CD137 for controlling Epstein-Barr virus (EBV) infections. (1) Mutations in CD137 predispose to EBV-associated diseases. (2) EBV induces ectopic CD137 expression, thereby activating a negative feed-back regulation and reducing T cell costimulation. These findings suggest CD137 agonists as new treatments for EBV-associated diseases.
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spelling pubmed-69594432020-01-30 Destroy, what destroys you Luu, Khang Nickles, Emily Schwarz, Herbert Oncoimmunology Point-of-View New evidence indicates the importance of CD137 for controlling Epstein-Barr virus (EBV) infections. (1) Mutations in CD137 predispose to EBV-associated diseases. (2) EBV induces ectopic CD137 expression, thereby activating a negative feed-back regulation and reducing T cell costimulation. These findings suggest CD137 agonists as new treatments for EBV-associated diseases. Taylor & Francis 2019-11-03 /pmc/articles/PMC6959443/ /pubmed/32002301 http://dx.doi.org/10.1080/2162402X.2019.1685301 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Point-of-View
Luu, Khang
Nickles, Emily
Schwarz, Herbert
Destroy, what destroys you
title Destroy, what destroys you
title_full Destroy, what destroys you
title_fullStr Destroy, what destroys you
title_full_unstemmed Destroy, what destroys you
title_short Destroy, what destroys you
title_sort destroy, what destroys you
topic Point-of-View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959443/
https://www.ncbi.nlm.nih.gov/pubmed/32002301
http://dx.doi.org/10.1080/2162402X.2019.1685301
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