Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapy

A substantial obstacle to the success of adoptive T cell-based cancer immunotherapy is the sub-optimal affinity of T-cell receptors (TCRs) for most tumor antigens. Genetically engineered TCRs that have enhanced affinity for specific tumor peptide-MHC complexes may overcome this barrier. However, thi...

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Detalles Bibliográficos
Autores principales: Sanderson, Joseph P, Crowley, Darragh J, Wiedermann, Guy E, Quinn, Laura L, Crossland, Katherine L, Tunbridge, Helen M, Cornforth, Terri V, Barnes, Christopher S, Ahmed, Tina, Howe, Karen, Saini, Manoj, Abbott, Rachel J, Anderson, Victoria E, Tavano, Barbara, Maroto, Miguel, Gerry, Andrew B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959444/
https://www.ncbi.nlm.nih.gov/pubmed/32002290
http://dx.doi.org/10.1080/2162402X.2019.1682381

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