B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models

The application of chimeric antigen receptor (CAR)-T cell therapy in patients with advanced solid tumors remains a significant challenge. Simultaneously targeting antigen and the solid tumor microenvironment are two major factors that greatly impact CAR-T cell therapy outcomes. In this study, we eng...

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Detalles Bibliográficos
Autores principales: Huang, Baozhu, Luo, Liqun, Wang, Jun, He, Bailin, Feng, Rui, Xian, Na, Zhang, Qiong, Chen, Lieping, Huang, Gangxiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959446/
https://www.ncbi.nlm.nih.gov/pubmed/32002297
http://dx.doi.org/10.1080/2162402X.2019.1684127

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