Calreticulin arms NK cells against leukemia

Calreticulin (CALR) exposed on the surface of cancer cells succumbing to therapy delivers robust phagocytic signals that support the activation of adaptive anticancer immune responses. Recent data from our group demonstrate that spontaneous CARL exposure on leukemic blasts also supports innate antic...

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Detalles Bibliográficos
Autores principales: Fucikova, Jitka, Kline, Justin P., Galluzzi, Lorenzo, Spisek, Radek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959451/
https://www.ncbi.nlm.nih.gov/pubmed/32002282
http://dx.doi.org/10.1080/2162402X.2019.1671763
Descripción
Sumario:Calreticulin (CALR) exposed on the surface of cancer cells succumbing to therapy delivers robust phagocytic signals that support the activation of adaptive anticancer immune responses. Recent data from our group demonstrate that spontaneous CARL exposure on leukemic blasts also supports innate anticancer immunity by natural killer (NK) cells via an indirect mechanism relying on myeloid CD11c(+)CD14(+) cells.

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