The promise of adoptive cellular immunotherapies in hepatocellular carcinoma

Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Current systemic therapies result only in modest benefits and new therapeutic options are critically needed. Some patients show promising clinical responses to immune checkpoint inhibitors, however, ad...

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Detalles Bibliográficos
Autores principales: Hendrickson, Peter G., Olson, Michael, Luetkens, Tim, Weston, Siani, Han, Tiffany, Atanackovic, Djordje, Fine, Gabriel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959455/
https://www.ncbi.nlm.nih.gov/pubmed/32002284
http://dx.doi.org/10.1080/2162402X.2019.1673129
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author Hendrickson, Peter G.
Olson, Michael
Luetkens, Tim
Weston, Siani
Han, Tiffany
Atanackovic, Djordje
Fine, Gabriel C.
author_facet Hendrickson, Peter G.
Olson, Michael
Luetkens, Tim
Weston, Siani
Han, Tiffany
Atanackovic, Djordje
Fine, Gabriel C.
author_sort Hendrickson, Peter G.
collection PubMed
description Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Current systemic therapies result only in modest benefits and new therapeutic options are critically needed. Some patients show promising clinical responses to immune checkpoint inhibitors, however, additional immunotherapeutic approaches, such as adoptive cell therapies (ACT), need to be developed. This review summarizes recent ACT studies and discusses the promise and obstacles of this approach. We further discuss ways of improving the efficacy of ACT in HCC including the use of combination therapies and locoregional delivery methods.
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spelling pubmed-69594552020-01-30 The promise of adoptive cellular immunotherapies in hepatocellular carcinoma Hendrickson, Peter G. Olson, Michael Luetkens, Tim Weston, Siani Han, Tiffany Atanackovic, Djordje Fine, Gabriel C. Oncoimmunology Review Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. Current systemic therapies result only in modest benefits and new therapeutic options are critically needed. Some patients show promising clinical responses to immune checkpoint inhibitors, however, additional immunotherapeutic approaches, such as adoptive cell therapies (ACT), need to be developed. This review summarizes recent ACT studies and discusses the promise and obstacles of this approach. We further discuss ways of improving the efficacy of ACT in HCC including the use of combination therapies and locoregional delivery methods. Taylor & Francis 2019-10-13 /pmc/articles/PMC6959455/ /pubmed/32002284 http://dx.doi.org/10.1080/2162402X.2019.1673129 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Hendrickson, Peter G.
Olson, Michael
Luetkens, Tim
Weston, Siani
Han, Tiffany
Atanackovic, Djordje
Fine, Gabriel C.
The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
title The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
title_full The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
title_fullStr The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
title_full_unstemmed The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
title_short The promise of adoptive cellular immunotherapies in hepatocellular carcinoma
title_sort promise of adoptive cellular immunotherapies in hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959455/
https://www.ncbi.nlm.nih.gov/pubmed/32002284
http://dx.doi.org/10.1080/2162402X.2019.1673129
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