Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction

Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased expression of the immune gene C4 has been linked to a greater risk of developing schizophrenia; however, it is not known whether C4 plays a causative role in this brain disorder. Using confocal imaging and whole-cel...

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Detalles Bibliográficos
Autores principales: Comer, Ashley L., Jinadasa, Tushare, Sriram, Balaji, Phadke, Rhushikesh A., Kretsge, Lisa N., Nguyen, Thanh P. H., Antognetti, Giovanna, Gilbert, James P., Lee, Jungjoon, Newmark, Elena R., Hausmann, Frances S., Rosenthal, SaraAnn, Liu Kot, Kevin, Liu, Yenyu, Yen, William W., Dejanovic, Borislav, Cruz-Martín, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959572/
https://www.ncbi.nlm.nih.gov/pubmed/31935214
http://dx.doi.org/10.1371/journal.pbio.3000604

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