Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression

Metastasis represents the greatest challenge to treatment of cancer patients. Biomaterial scaffolds that recruit tumor cells to a defined site in vivo are an emerging platform for the diagnosis, treatment, and study of metastasis. Recruitment of immune cells and metastatic tumor cells to a defined l...

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Detalles Bibliográficos
Autores principales: Bushnell, Grace G., Wicha, Max S., Jeruss, Jacqueline S., Shea, Lonnie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959931/
https://www.ncbi.nlm.nih.gov/pubmed/31984215
http://dx.doi.org/10.18632/oncoscience.493
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author Bushnell, Grace G.
Wicha, Max S.
Jeruss, Jacqueline S.
Shea, Lonnie D.
author_facet Bushnell, Grace G.
Wicha, Max S.
Jeruss, Jacqueline S.
Shea, Lonnie D.
author_sort Bushnell, Grace G.
collection PubMed
description Metastasis represents the greatest challenge to treatment of cancer patients. Biomaterial scaffolds that recruit tumor cells to a defined site in vivo are an emerging platform for the diagnosis, treatment, and study of metastasis. Recruitment of immune cells and metastatic tumor cells to a defined location provides a precision health platform to assess current clinical cancer biomarkers in a metastatic setting, and to define the next generation of biomarkers. These platforms represent an opportunity to create a molecular staging of metastasis that could aid in both the early diagnosis and treatment of metastasis.
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spelling pubmed-69599312020-01-24 Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression Bushnell, Grace G. Wicha, Max S. Jeruss, Jacqueline S. Shea, Lonnie D. Oncoscience Research Perspective Metastasis represents the greatest challenge to treatment of cancer patients. Biomaterial scaffolds that recruit tumor cells to a defined site in vivo are an emerging platform for the diagnosis, treatment, and study of metastasis. Recruitment of immune cells and metastatic tumor cells to a defined location provides a precision health platform to assess current clinical cancer biomarkers in a metastatic setting, and to define the next generation of biomarkers. These platforms represent an opportunity to create a molecular staging of metastasis that could aid in both the early diagnosis and treatment of metastasis. Impact Journals LLC 2019-12-23 /pmc/articles/PMC6959931/ /pubmed/31984215 http://dx.doi.org/10.18632/oncoscience.493 Text en Copyright: © 2019 Bushnell et al. https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Perspective
Bushnell, Grace G.
Wicha, Max S.
Jeruss, Jacqueline S.
Shea, Lonnie D.
Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression
title Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression
title_full Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression
title_fullStr Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression
title_full_unstemmed Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression
title_short Precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression
title_sort precision health for breast cancer metastasis: biomaterial scaffolds as an engineered metastatic niche to define, study, and monitor metastatic progression
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959931/
https://www.ncbi.nlm.nih.gov/pubmed/31984215
http://dx.doi.org/10.18632/oncoscience.493
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