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Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis

BACKGROUND: Adjuvant endocrine therapy is a vital portion of postoperative comprehensive treatment for breast cancer patients. In recent years, studies have shown that endocrine therapy has a certain impact on the serum lipids of breast cancer patients, and the changes of lipid profiles may bring a...

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Autores principales: He, Tao, Yang, Wenhao, Zhang, Xinyi, Li, Ping, Yang, Dandan, Wu, Yunhao, Fan, Yuan, Xiang, Mengya, Huang, Qianqian, Chen, Jing, Zhou, Runke, Lv, Qing, Chen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959941/
https://www.ncbi.nlm.nih.gov/pubmed/31914031
http://dx.doi.org/10.1097/MD.0000000000018550
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author He, Tao
Yang, Wenhao
Zhang, Xinyi
Li, Ping
Yang, Dandan
Wu, Yunhao
Fan, Yuan
Xiang, Mengya
Huang, Qianqian
Chen, Jing
Zhou, Runke
Lv, Qing
Chen, Jie
author_facet He, Tao
Yang, Wenhao
Zhang, Xinyi
Li, Ping
Yang, Dandan
Wu, Yunhao
Fan, Yuan
Xiang, Mengya
Huang, Qianqian
Chen, Jing
Zhou, Runke
Lv, Qing
Chen, Jie
author_sort He, Tao
collection PubMed
description BACKGROUND: Adjuvant endocrine therapy is a vital portion of postoperative comprehensive treatment for breast cancer patients. In recent years, studies have shown that endocrine therapy has a certain impact on the serum lipids of breast cancer patients, and the changes of lipid profiles may bring a series of problems. However, very few studies focus on this issue to date. The results of these studies are inconsistent, and the influence of different adjuvant endocrine modalities on lipid profiles still remains controversial. In order to better explore this issue, we conduct this network meta-analysis. METHOD: The protocol followed preferred reporting items for systematic reviews and meta-analyses protocols. Three main databases (PubMed, Embase, and the Cochrane Library) will be searched systematically for eligible randomized controlled trials without language restriction. In addition, a manual search of the references of relevant published studies will also be considered. Two reviewers will conduct studies selection, data extraction, and risk of bias assessment independently. The primary outcome is the variation of biochemical parameters – the serum lipid profiles (cholesterol, triglyceride, high-density lipoprotein, low low-density lipoprotein). RESULTS: The results will provide useful information about the side effects of different adjuvant endocrine drugs on lipid profiles in postoperative breast cancer patients (estrogen receptor-positive and/or progesterone receptor-positive). CONCLUSION: The findings of this study will be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42019129850.
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spelling pubmed-69599412020-01-31 Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis He, Tao Yang, Wenhao Zhang, Xinyi Li, Ping Yang, Dandan Wu, Yunhao Fan, Yuan Xiang, Mengya Huang, Qianqian Chen, Jing Zhou, Runke Lv, Qing Chen, Jie Medicine (Baltimore) 5700 BACKGROUND: Adjuvant endocrine therapy is a vital portion of postoperative comprehensive treatment for breast cancer patients. In recent years, studies have shown that endocrine therapy has a certain impact on the serum lipids of breast cancer patients, and the changes of lipid profiles may bring a series of problems. However, very few studies focus on this issue to date. The results of these studies are inconsistent, and the influence of different adjuvant endocrine modalities on lipid profiles still remains controversial. In order to better explore this issue, we conduct this network meta-analysis. METHOD: The protocol followed preferred reporting items for systematic reviews and meta-analyses protocols. Three main databases (PubMed, Embase, and the Cochrane Library) will be searched systematically for eligible randomized controlled trials without language restriction. In addition, a manual search of the references of relevant published studies will also be considered. Two reviewers will conduct studies selection, data extraction, and risk of bias assessment independently. The primary outcome is the variation of biochemical parameters – the serum lipid profiles (cholesterol, triglyceride, high-density lipoprotein, low low-density lipoprotein). RESULTS: The results will provide useful information about the side effects of different adjuvant endocrine drugs on lipid profiles in postoperative breast cancer patients (estrogen receptor-positive and/or progesterone receptor-positive). CONCLUSION: The findings of this study will be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42019129850. Wolters Kluwer Health 2020-01-10 /pmc/articles/PMC6959941/ /pubmed/31914031 http://dx.doi.org/10.1097/MD.0000000000018550 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
He, Tao
Yang, Wenhao
Zhang, Xinyi
Li, Ping
Yang, Dandan
Wu, Yunhao
Fan, Yuan
Xiang, Mengya
Huang, Qianqian
Chen, Jing
Zhou, Runke
Lv, Qing
Chen, Jie
Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis
title Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis
title_full Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis
title_fullStr Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis
title_full_unstemmed Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis
title_short Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis
title_sort comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: a network meta-analysis
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959941/
https://www.ncbi.nlm.nih.gov/pubmed/31914031
http://dx.doi.org/10.1097/MD.0000000000018550
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