MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity

Metastasis is a major cause of cancer mortality. We generated an autochthonous transgenic mouse model whereby conditional expression of MYC and Twist1 enables hepatocellular carcinoma (HCC) to metastasize in >90% of mice. MYC and Twist1 cooperate and their sustained expression is required to elic...

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Detalles Bibliográficos
Autores principales: Dhanasekaran, Renumathy, Baylot, Virginie, Kim, Minsoon, Kuruvilla, Sibu, Bellovin, David I, Adeniji, Nia, Rajan KD, Anand, Lai, Ian, Gabay, Meital, Tong, Ling, Krishnan, Maya, Park, Jangho, Hu, Theodore, Barbhuiya, Mustafa A, Gentles, Andrew J, Kannan, Kasthuri, Tran, Phuoc T, Felsher, Dean W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959993/
https://www.ncbi.nlm.nih.gov/pubmed/31933479
http://dx.doi.org/10.7554/eLife.50731

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