Cargando…
Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
BACKGROUND/AIMS: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis. METHODS: We retrospectively collected dat...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960044/ https://www.ncbi.nlm.nih.gov/pubmed/30791681 http://dx.doi.org/10.3904/kjim.2018.151 |
_version_ | 1783487704367890432 |
---|---|
author | Lee, Jae Gon Sohn, Joo Hyun Jeong, Jae Yoon Kim, Tae Yeob Kim, Sun Min Cho, Young Seo Kim, Yongsoo |
author_facet | Lee, Jae Gon Sohn, Joo Hyun Jeong, Jae Yoon Kim, Tae Yeob Kim, Sun Min Cho, Young Seo Kim, Yongsoo |
author_sort | Lee, Jae Gon |
collection | PubMed |
description | BACKGROUND/AIMS: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis. METHODS: We retrospectively collected data from 103 patients with cirrhosis, whose HVPG and LS were measured between November 2009 and September 2013. The patients were divided into four groups according to the results of the HVPG and LS measurements. Long-term mortality and the risk factors for mortality were analyzed. RESULTS: Of the 103 patients, 35 were in group 1 (low HVPG and low LS), 16 in group 2 (high HVPG and low LS), 24 in group 3 (low HVPG and high LS), and 28 in group 4 (high HVPG and high LS). Over a median follow-up of 47.3 months, 18 patients died. The mortality rate of patients in group 4 was significantly higher than in the other three groups (vs. group 1, p = 0.005; vs. group 2, p = 0.049; vs. group 3, p = 0.004), but there were no significant differences in survival between groups 1, 2, and 3. In multivariable analyses, both HVPG and LS were identified as independent risk factors for mortality (hazard ratio [HR], 1.127, p = 0.018; and HR, 1.062, p = 0.009, respectively). CONCLUSIONS: In patients with cirrhosis, those with concurrent elevation of HVPG and LS had the highest long-term mortality rates. However, when either HVPG or LS alone was elevated, mortality did not increase significantly. |
format | Online Article Text |
id | pubmed-6960044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-69600442020-01-22 Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis Lee, Jae Gon Sohn, Joo Hyun Jeong, Jae Yoon Kim, Tae Yeob Kim, Sun Min Cho, Young Seo Kim, Yongsoo Korean J Intern Med Original Article BACKGROUND/AIMS: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis. METHODS: We retrospectively collected data from 103 patients with cirrhosis, whose HVPG and LS were measured between November 2009 and September 2013. The patients were divided into four groups according to the results of the HVPG and LS measurements. Long-term mortality and the risk factors for mortality were analyzed. RESULTS: Of the 103 patients, 35 were in group 1 (low HVPG and low LS), 16 in group 2 (high HVPG and low LS), 24 in group 3 (low HVPG and high LS), and 28 in group 4 (high HVPG and high LS). Over a median follow-up of 47.3 months, 18 patients died. The mortality rate of patients in group 4 was significantly higher than in the other three groups (vs. group 1, p = 0.005; vs. group 2, p = 0.049; vs. group 3, p = 0.004), but there were no significant differences in survival between groups 1, 2, and 3. In multivariable analyses, both HVPG and LS were identified as independent risk factors for mortality (hazard ratio [HR], 1.127, p = 0.018; and HR, 1.062, p = 0.009, respectively). CONCLUSIONS: In patients with cirrhosis, those with concurrent elevation of HVPG and LS had the highest long-term mortality rates. However, when either HVPG or LS alone was elevated, mortality did not increase significantly. The Korean Association of Internal Medicine 2020-01 2019-02-25 /pmc/articles/PMC6960044/ /pubmed/30791681 http://dx.doi.org/10.3904/kjim.2018.151 Text en Copyright © 2020 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Jae Gon Sohn, Joo Hyun Jeong, Jae Yoon Kim, Tae Yeob Kim, Sun Min Cho, Young Seo Kim, Yongsoo Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis |
title | Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis |
title_full | Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis |
title_fullStr | Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis |
title_full_unstemmed | Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis |
title_short | Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis |
title_sort | combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960044/ https://www.ncbi.nlm.nih.gov/pubmed/30791681 http://dx.doi.org/10.3904/kjim.2018.151 |
work_keys_str_mv | AT leejaegon combinedeffectofhepaticvenouspressuregradientandliverstiffnessonlongtermmortalityinpatientswithcirrhosis AT sohnjoohyun combinedeffectofhepaticvenouspressuregradientandliverstiffnessonlongtermmortalityinpatientswithcirrhosis AT jeongjaeyoon combinedeffectofhepaticvenouspressuregradientandliverstiffnessonlongtermmortalityinpatientswithcirrhosis AT kimtaeyeob combinedeffectofhepaticvenouspressuregradientandliverstiffnessonlongtermmortalityinpatientswithcirrhosis AT kimsunmin combinedeffectofhepaticvenouspressuregradientandliverstiffnessonlongtermmortalityinpatientswithcirrhosis AT choyoungseo combinedeffectofhepaticvenouspressuregradientandliverstiffnessonlongtermmortalityinpatientswithcirrhosis AT kimyongsoo combinedeffectofhepaticvenouspressuregradientandliverstiffnessonlongtermmortalityinpatientswithcirrhosis |