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Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis

BACKGROUND/AIMS: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis. METHODS: We retrospectively collected dat...

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Autores principales: Lee, Jae Gon, Sohn, Joo Hyun, Jeong, Jae Yoon, Kim, Tae Yeob, Kim, Sun Min, Cho, Young Seo, Kim, Yongsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960044/
https://www.ncbi.nlm.nih.gov/pubmed/30791681
http://dx.doi.org/10.3904/kjim.2018.151
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author Lee, Jae Gon
Sohn, Joo Hyun
Jeong, Jae Yoon
Kim, Tae Yeob
Kim, Sun Min
Cho, Young Seo
Kim, Yongsoo
author_facet Lee, Jae Gon
Sohn, Joo Hyun
Jeong, Jae Yoon
Kim, Tae Yeob
Kim, Sun Min
Cho, Young Seo
Kim, Yongsoo
author_sort Lee, Jae Gon
collection PubMed
description BACKGROUND/AIMS: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis. METHODS: We retrospectively collected data from 103 patients with cirrhosis, whose HVPG and LS were measured between November 2009 and September 2013. The patients were divided into four groups according to the results of the HVPG and LS measurements. Long-term mortality and the risk factors for mortality were analyzed. RESULTS: Of the 103 patients, 35 were in group 1 (low HVPG and low LS), 16 in group 2 (high HVPG and low LS), 24 in group 3 (low HVPG and high LS), and 28 in group 4 (high HVPG and high LS). Over a median follow-up of 47.3 months, 18 patients died. The mortality rate of patients in group 4 was significantly higher than in the other three groups (vs. group 1, p = 0.005; vs. group 2, p = 0.049; vs. group 3, p = 0.004), but there were no significant differences in survival between groups 1, 2, and 3. In multivariable analyses, both HVPG and LS were identified as independent risk factors for mortality (hazard ratio [HR], 1.127, p = 0.018; and HR, 1.062, p = 0.009, respectively). CONCLUSIONS: In patients with cirrhosis, those with concurrent elevation of HVPG and LS had the highest long-term mortality rates. However, when either HVPG or LS alone was elevated, mortality did not increase significantly.
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spelling pubmed-69600442020-01-22 Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis Lee, Jae Gon Sohn, Joo Hyun Jeong, Jae Yoon Kim, Tae Yeob Kim, Sun Min Cho, Young Seo Kim, Yongsoo Korean J Intern Med Original Article BACKGROUND/AIMS: Both hepatic venous pressure gradient (HVPG) and liver stiffness (LS) are useful tools for predicting mortality in patients with cirrhosis. We investigated the combined effect of HVPG and LS on long-term mortality in patients with cirrhosis. METHODS: We retrospectively collected data from 103 patients with cirrhosis, whose HVPG and LS were measured between November 2009 and September 2013. The patients were divided into four groups according to the results of the HVPG and LS measurements. Long-term mortality and the risk factors for mortality were analyzed. RESULTS: Of the 103 patients, 35 were in group 1 (low HVPG and low LS), 16 in group 2 (high HVPG and low LS), 24 in group 3 (low HVPG and high LS), and 28 in group 4 (high HVPG and high LS). Over a median follow-up of 47.3 months, 18 patients died. The mortality rate of patients in group 4 was significantly higher than in the other three groups (vs. group 1, p = 0.005; vs. group 2, p = 0.049; vs. group 3, p = 0.004), but there were no significant differences in survival between groups 1, 2, and 3. In multivariable analyses, both HVPG and LS were identified as independent risk factors for mortality (hazard ratio [HR], 1.127, p = 0.018; and HR, 1.062, p = 0.009, respectively). CONCLUSIONS: In patients with cirrhosis, those with concurrent elevation of HVPG and LS had the highest long-term mortality rates. However, when either HVPG or LS alone was elevated, mortality did not increase significantly. The Korean Association of Internal Medicine 2020-01 2019-02-25 /pmc/articles/PMC6960044/ /pubmed/30791681 http://dx.doi.org/10.3904/kjim.2018.151 Text en Copyright © 2020 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Jae Gon
Sohn, Joo Hyun
Jeong, Jae Yoon
Kim, Tae Yeob
Kim, Sun Min
Cho, Young Seo
Kim, Yongsoo
Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
title Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
title_full Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
title_fullStr Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
title_full_unstemmed Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
title_short Combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
title_sort combined effect of hepatic venous pressure gradient and liver stiffness on long-term mortality in patients with cirrhosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960044/
https://www.ncbi.nlm.nih.gov/pubmed/30791681
http://dx.doi.org/10.3904/kjim.2018.151
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