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Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity

BACKGROUND/AIMS: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. METHODS: This was...

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Autores principales: Shin, Kichul, Kim, Sung Soo, Lee, Sang-Heon, Hong, Seung-Jae, Choi, Sung Jae, Choe, Jung-Yoon, Lee, Seung-Geun, Cha, Hoon-Suk, Lee, Eun Young, Park, Sung-Hwan, Hur, Jin-Wuk, Na, Sung Soo, Suh, Chang-Hee, So, Min Wook, Choi, Seung Won, Sheen, Dong-Hyuk, Park, Won, Lee, Shin-Seok, Ryu, Wan Hee, Kim, Jin Seok, Song, Jung Soo, Lee, Hye Soon, Kim, Seong Ho, Yoo, Dae-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960052/
https://www.ncbi.nlm.nih.gov/pubmed/30685961
http://dx.doi.org/10.3904/kjim.2018.137
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author Shin, Kichul
Kim, Sung Soo
Lee, Sang-Heon
Hong, Seung-Jae
Choi, Sung Jae
Choe, Jung-Yoon
Lee, Seung-Geun
Cha, Hoon-Suk
Lee, Eun Young
Park, Sung-Hwan
Hur, Jin-Wuk
Na, Sung Soo
Suh, Chang-Hee
So, Min Wook
Choi, Seung Won
Sheen, Dong-Hyuk
Park, Won
Lee, Shin-Seok
Ryu, Wan Hee
Kim, Jin Seok
Song, Jung Soo
Lee, Hye Soon
Kim, Seong Ho
Yoo, Dae-Hyun
author_facet Shin, Kichul
Kim, Sung Soo
Lee, Sang-Heon
Hong, Seung-Jae
Choi, Sung Jae
Choe, Jung-Yoon
Lee, Seung-Geun
Cha, Hoon-Suk
Lee, Eun Young
Park, Sung-Hwan
Hur, Jin-Wuk
Na, Sung Soo
Suh, Chang-Hee
So, Min Wook
Choi, Seung Won
Sheen, Dong-Hyuk
Park, Won
Lee, Shin-Seok
Ryu, Wan Hee
Kim, Jin Seok
Song, Jung Soo
Lee, Hye Soon
Kim, Seong Ho
Yoo, Dae-Hyun
author_sort Shin, Kichul
collection PubMed
description BACKGROUND/AIMS: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. METHODS: This was a nationwide multicenter observational study. Patients who had three or more active joint counts and abnormal inf lammatory marker in blood test were enrolled. The selection of DMARDs was determined by the attending rheumatologist. Clinical parameters, laboratory findings, and Health Assessment Questionnaire (HAQ) scores were obtained at baseline and at 6 and 12 months. Serial SDAI changes and clinical remission rate at 6 and 12 months were assessed. RESULTS: A total of 850 patients participated in this study. The mean baseline SDAI score in bDMARD group was higher than that in cDMARD group (32.08 ± 12.98 vs 25.69 ± 10.97, p < 0.0001). Mean change of SDAI at 12 months was –19.0 in the bDMARD group and –12.6 in the cDMARD group (p < 0.0001). Clinical remission rates at 12 months in bDMARD and cDMARD groups were 15.4% and 14.6%, respectively. Patient global assessment and HAQ at 12 months were also significantly improved in both groups. Multivariate logistic regression showed that baseline HAQ score was the most notable factor associated with remission. CONCLUSIONS: There was a significant reduction in SDAI within 12 months after receiving DMARDs in Korean seropositive RA patients irrespective of bDMARD or cDMARD use in real-world practice. Clinical remission was achieved in those with lower baseline HAQ scores.
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spelling pubmed-69600522020-01-22 Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity Shin, Kichul Kim, Sung Soo Lee, Sang-Heon Hong, Seung-Jae Choi, Sung Jae Choe, Jung-Yoon Lee, Seung-Geun Cha, Hoon-Suk Lee, Eun Young Park, Sung-Hwan Hur, Jin-Wuk Na, Sung Soo Suh, Chang-Hee So, Min Wook Choi, Seung Won Sheen, Dong-Hyuk Park, Won Lee, Shin-Seok Ryu, Wan Hee Kim, Jin Seok Song, Jung Soo Lee, Hye Soon Kim, Seong Ho Yoo, Dae-Hyun Korean J Intern Med Original Article BACKGROUND/AIMS: The objective of this study was to compare changes in the simplified disease activity index (SDAI) between biologic (b) and conventional (c) disease-modifying antirheumatic drugs (DMARD) users with seropositive rheumatoid arthritis (RA) in daily clinical practice. METHODS: This was a nationwide multicenter observational study. Patients who had three or more active joint counts and abnormal inf lammatory marker in blood test were enrolled. The selection of DMARDs was determined by the attending rheumatologist. Clinical parameters, laboratory findings, and Health Assessment Questionnaire (HAQ) scores were obtained at baseline and at 6 and 12 months. Serial SDAI changes and clinical remission rate at 6 and 12 months were assessed. RESULTS: A total of 850 patients participated in this study. The mean baseline SDAI score in bDMARD group was higher than that in cDMARD group (32.08 ± 12.98 vs 25.69 ± 10.97, p < 0.0001). Mean change of SDAI at 12 months was –19.0 in the bDMARD group and –12.6 in the cDMARD group (p < 0.0001). Clinical remission rates at 12 months in bDMARD and cDMARD groups were 15.4% and 14.6%, respectively. Patient global assessment and HAQ at 12 months were also significantly improved in both groups. Multivariate logistic regression showed that baseline HAQ score was the most notable factor associated with remission. CONCLUSIONS: There was a significant reduction in SDAI within 12 months after receiving DMARDs in Korean seropositive RA patients irrespective of bDMARD or cDMARD use in real-world practice. Clinical remission was achieved in those with lower baseline HAQ scores. The Korean Association of Internal Medicine 2020-01 2019-01-28 /pmc/articles/PMC6960052/ /pubmed/30685961 http://dx.doi.org/10.3904/kjim.2018.137 Text en Copyright © 2020 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shin, Kichul
Kim, Sung Soo
Lee, Sang-Heon
Hong, Seung-Jae
Choi, Sung Jae
Choe, Jung-Yoon
Lee, Seung-Geun
Cha, Hoon-Suk
Lee, Eun Young
Park, Sung-Hwan
Hur, Jin-Wuk
Na, Sung Soo
Suh, Chang-Hee
So, Min Wook
Choi, Seung Won
Sheen, Dong-Hyuk
Park, Won
Lee, Shin-Seok
Ryu, Wan Hee
Kim, Jin Seok
Song, Jung Soo
Lee, Hye Soon
Kim, Seong Ho
Yoo, Dae-Hyun
Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
title Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
title_full Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
title_fullStr Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
title_full_unstemmed Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
title_short Simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
title_sort simplified disease activity changes in real-world practice: a nationwide observational study of seropositive rheumatoid arthritis patients with moderate-to-high disease activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960052/
https://www.ncbi.nlm.nih.gov/pubmed/30685961
http://dx.doi.org/10.3904/kjim.2018.137
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