Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis

Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy. Objective: To demonstrate whether IgM memory B cells are necessary for generating Ig...

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Detalles Bibliográficos
Autores principales: Carsetti, Rita, Di Sabatino, Antonio, Rosado, Maria Manuela, Cascioli, Simona, Piano Mortari, Eva, Milito, Cinzia, Grimsholm, Ola, Aranburu, Alaitz, Giorda, Ezio, Tinozzi, Francesco Paolo, Pulvirenti, Federica, Donato, Giuseppe, Morini, Francesco, Bagolan, Pietro, Corazza, Gino Roberto, Quinti, Isabella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960143/
https://www.ncbi.nlm.nih.gov/pubmed/31969880
http://dx.doi.org/10.3389/fimmu.2019.02937

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