Cargando…

Withanolide D Enhances Radiosensitivity of Human Cancer Cells by Inhibiting DNA Damage Non-homologous End Joining Repair Pathway

Along with surgery and chemotherapy, radiation therapy (RT) is an important modality in cancer treatment, and the development of radiosensitizers is a current key challenge in radiobiology to maximize RT efficiency. In this study, the radiosensitizing effect of a natural compound from the withanolid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lacombe, Jerome, Cretignier, Titouan, Meli, Laetitia, Wijeratne, E. M. Kithsiri, Veuthey, Jean-Luc, Cuendet, Muriel, Gunatilaka, A. A. Leslie, Zenhausern, Frederic
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960174/ https://www.ncbi.nlm.nih.gov/pubmed/31970089 http://dx.doi.org/10.3389/fonc.2019.01468

Ejemplares similares

Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells
por: Issa, Mark E., et al.
Publicado: (2017)

Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl
por: Xu, Ya-Ming, et al.
Publicado: (2022)

Endohyphal Bacterium Enhances Production of Indole-3-Acetic Acid by a Foliar Fungal Endophyte
por: Hoffman, Michele T., et al.
Publicado: (2013)

Effect of mechanical forces on cellular response to radiation
por: Lacombe, Jerome, et al.
Publicado: (2022)

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination
por: Chitnis, Meenali M., et al.
Publicado: (2013)

The spatial organization of non-homologous end joining: From bridging to end joining
por: Ochi, Takashi, et al.
Publicado: (2014)

Plant-Based Scaffolds Modify Cellular Response to Drug and Radiation Exposure Compared to Standard Cell Culture Models
por: Lacombe, Jerome, et al.
Publicado: (2020)

The Emerging Role of Decellularized Plant-Based Scaffolds as a New Biomaterial
por: Harris, Ashlee F., et al.
Publicado: (2021)

Thielavialides A–E, Nor-Spiro-azaphilones, and a Bis-spiro-azaphilone from Thielavia sp. PA0001, An Endophytic Fungus Isolated from Aeroponically Grown Physalis alkekengi†
por: Wijeratne, E. M. Kithsiri, et al.
Publicado: (2014)

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining
por: Moureau, Sylvie, et al.
Publicado: (2016)

Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: A systematic review
por: Lacombe, Jerome, et al.
Publicado: (2018)

Non-homologous end joining in class switch recombination: the beginning of the end
por: Kotnis, Ashwin, et al.
Publicado: (2008)

PIAS3 promotes homology-directed repair and distal non-homologous end joining
por: LIU, SHICUI, et al.
Publicado: (2013)

Homology and enzymatic requirements of microhomology-dependent alternative end joining
por: Sharma, S, et al.
Publicado: (2015)

DNA non-homologous end-joining enters the resection arena
por: Jeggo, Penny A., et al.
Publicado: (2017)

Non-homologous end joining repair in Xenopus egg extract
por: Zhu, Songli, et al.
Publicado: (2016)

Change of Gene Structure and Function by Non-Homologous End-Joining, Homologous Recombination, and Transposition of DNA
por: Goettel, Wolfgang, et al.
Publicado: (2009)

Measuring nonhomologous end-joining, homologous recombination and alternative end-joining simultaneously at an endogenous locus in any transfectable human cell
por: Hussain, Suleman S, et al.
Publicado: (2021)

Establishment of a Transformation Coupled in vitro End Joining Assay to Estimate Radiosensitivity in Tumor Cells
por: Degenhardt, Sarah, et al.
Publicado: (2020)

Natural Withanolides in the Treatment of Chronic Diseases
por: White, Peter T., et al.
Publicado: (2016)

Withanolides from Physalis angulata L.
por: Okmanov, R. Ya., et al.
Publicado: (2021)

Merotelic attachments and non-homologous end joining are the basis of chromosomal instability
por: Guerrero, Astrid Alonso, et al.
Publicado: (2010)

The non-homologous end-joining pathway is involved in stable transformation in rice
por: Saika, Hiroaki, et al.
Publicado: (2014)

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?
por: Bétermier, Mireille, et al.
Publicado: (2014)

Lif1 SUMOylation and its role in non-homologous end-joining
por: Vigasova, Dana, et al.
Publicado: (2013)

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer
por: Sishc, Brock J., et al.
Publicado: (2017)

Canonical DNA non-homologous end-joining; capacity versus fidelity
por: Shibata, Atsushi, et al.
Publicado: (2020)

The Fate of Linear DNA in Saccharomyces cerevisiae and Candida glabrata: The Role of Homologous and Non-Homologous End Joining
por: Corrigan, Mary W., et al.
Publicado: (2013)

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining
por: Szymonowicz, Klaudia, et al.
Publicado: (2020)

Making Ends Meet: Repairing Breaks in Bacterial DNA by Non-Homologous End-Joining
por: Bowater, Richard, et al.
Publicado: (2006)

End-processing during non-homologous end-joining: a role for exonuclease 1
por: Bahmed, Karim, et al.
Publicado: (2011)

One end to rule them all: Non-homologous end-joining and homologous recombination at DNA double-strand breaks
por: Ensminger, Michael, et al.
Publicado: (2020)

Ancient and Recent Adaptive Evolution of Primate Non-Homologous End Joining Genes
por: Demogines, Ann, et al.
Publicado: (2010)

Role of mammalian Mre11 in classical and alternative non-homologous end joining
por: Xie, Anyong, et al.
Publicado: (2009)

Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ
por: Martin, Maria Jose, et al.
Publicado: (2013)

Modeling Damage Complexity-Dependent Non-Homologous End-Joining Repair Pathway
por: Li, Yongfeng, et al.
Publicado: (2014)

A role for protein phosphatase 4 in regulating non-homologous end-joining
por: Davis, Anthony J., et al.
Publicado: (2012)

Heat shock factor 1, an inhibitor of non-homologous end joining repair
por: Kang, Ga-Young, et al.
Publicado: (2015)

PHRF1 promotes genome integrity by modulating non-homologous end-joining
por: Chang, C-F, et al.
Publicado: (2015)

Long noncoding RNA LINP1: scaffolding non-homologous end joining
por: Sakthianandeswaren, A, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_alvd13vu5st834s2o4tl8flu2s