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Recent Advances in Meningioma Immunogenetics

Meningiomas are relatively common, and typically benign intracranial tumors, which in many cases can be cured by surgical resection. However, less prevalent, high grade meningiomas, grow quickly, and recur frequently despite treatment, leading to poor patient outcomes. Across tumor grades, subjectiv...

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Detalles Bibliográficos
Autores principales: Al-Rashed, May, Foshay, Kara, Abedalthagafi, Malak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960175/
https://www.ncbi.nlm.nih.gov/pubmed/31970090
http://dx.doi.org/10.3389/fonc.2019.01472
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author Al-Rashed, May
Foshay, Kara
Abedalthagafi, Malak
author_facet Al-Rashed, May
Foshay, Kara
Abedalthagafi, Malak
author_sort Al-Rashed, May
collection PubMed
description Meningiomas are relatively common, and typically benign intracranial tumors, which in many cases can be cured by surgical resection. However, less prevalent, high grade meningiomas, grow quickly, and recur frequently despite treatment, leading to poor patient outcomes. Across tumor grades, subjective guidelines for histological analysis can preclude accurate diagnosis, and an insufficient understanding of recurrence risk can cloud the choice of optimal treatment. Improved diagnostic and prognostic markers capable of discerning between the 15 heterogeneous WHO recognized meningioma subtypes are necessary to improve disease management and identify new targeted drug treatments. In this review, we show the advances in molecular profiling and immunophenotyping of meningiomas, which may lead to the development of new personalized therapeutic strategies.
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spelling pubmed-69601752020-01-22 Recent Advances in Meningioma Immunogenetics Al-Rashed, May Foshay, Kara Abedalthagafi, Malak Front Oncol Oncology Meningiomas are relatively common, and typically benign intracranial tumors, which in many cases can be cured by surgical resection. However, less prevalent, high grade meningiomas, grow quickly, and recur frequently despite treatment, leading to poor patient outcomes. Across tumor grades, subjective guidelines for histological analysis can preclude accurate diagnosis, and an insufficient understanding of recurrence risk can cloud the choice of optimal treatment. Improved diagnostic and prognostic markers capable of discerning between the 15 heterogeneous WHO recognized meningioma subtypes are necessary to improve disease management and identify new targeted drug treatments. In this review, we show the advances in molecular profiling and immunophenotyping of meningiomas, which may lead to the development of new personalized therapeutic strategies. Frontiers Media S.A. 2020-01-08 /pmc/articles/PMC6960175/ /pubmed/31970090 http://dx.doi.org/10.3389/fonc.2019.01472 Text en Copyright © 2020 Al-Rashed, Foshay and Abedalthagafi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Al-Rashed, May
Foshay, Kara
Abedalthagafi, Malak
Recent Advances in Meningioma Immunogenetics
title Recent Advances in Meningioma Immunogenetics
title_full Recent Advances in Meningioma Immunogenetics
title_fullStr Recent Advances in Meningioma Immunogenetics
title_full_unstemmed Recent Advances in Meningioma Immunogenetics
title_short Recent Advances in Meningioma Immunogenetics
title_sort recent advances in meningioma immunogenetics
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960175/
https://www.ncbi.nlm.nih.gov/pubmed/31970090
http://dx.doi.org/10.3389/fonc.2019.01472
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