Sarcoidosis as an Autoimmune Disease

Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an a...

Descripción completa

Detalles Bibliográficos
Autores principales: Starshinova, Anna A., Malkova, Anna M., Basantsova, Natalia Y., Zinchenko, Yulia S., Kudryavtsev, Igor V., Ershov, Gennadiy A., Soprun, Lidia A., Mayevskaya, Vera A., Churilov, Leonid P., Yablonskiy, Piotr K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960207/
https://www.ncbi.nlm.nih.gov/pubmed/31969879
http://dx.doi.org/10.3389/fimmu.2019.02933
_version_ 1783487743069782016
author Starshinova, Anna A.
Malkova, Anna M.
Basantsova, Natalia Y.
Zinchenko, Yulia S.
Kudryavtsev, Igor V.
Ershov, Gennadiy A.
Soprun, Lidia A.
Mayevskaya, Vera A.
Churilov, Leonid P.
Yablonskiy, Piotr K.
author_facet Starshinova, Anna A.
Malkova, Anna M.
Basantsova, Natalia Y.
Zinchenko, Yulia S.
Kudryavtsev, Igor V.
Ershov, Gennadiy A.
Soprun, Lidia A.
Mayevskaya, Vera A.
Churilov, Leonid P.
Yablonskiy, Piotr K.
author_sort Starshinova, Anna A.
collection PubMed
description Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and “classic” autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.
format Online
Article
Text
id pubmed-6960207
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-69602072020-01-22 Sarcoidosis as an Autoimmune Disease Starshinova, Anna A. Malkova, Anna M. Basantsova, Natalia Y. Zinchenko, Yulia S. Kudryavtsev, Igor V. Ershov, Gennadiy A. Soprun, Lidia A. Mayevskaya, Vera A. Churilov, Leonid P. Yablonskiy, Piotr K. Front Immunol Immunology Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and “classic” autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life. Frontiers Media S.A. 2020-01-08 /pmc/articles/PMC6960207/ /pubmed/31969879 http://dx.doi.org/10.3389/fimmu.2019.02933 Text en Copyright © 2020 Starshinova, Malkova, Basantsova, Zinchenko, Kudryavtsev, Ershov, Soprun, Mayevskaya, Churilov and Yablonskiy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Starshinova, Anna A.
Malkova, Anna M.
Basantsova, Natalia Y.
Zinchenko, Yulia S.
Kudryavtsev, Igor V.
Ershov, Gennadiy A.
Soprun, Lidia A.
Mayevskaya, Vera A.
Churilov, Leonid P.
Yablonskiy, Piotr K.
Sarcoidosis as an Autoimmune Disease
title Sarcoidosis as an Autoimmune Disease
title_full Sarcoidosis as an Autoimmune Disease
title_fullStr Sarcoidosis as an Autoimmune Disease
title_full_unstemmed Sarcoidosis as an Autoimmune Disease
title_short Sarcoidosis as an Autoimmune Disease
title_sort sarcoidosis as an autoimmune disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960207/
https://www.ncbi.nlm.nih.gov/pubmed/31969879
http://dx.doi.org/10.3389/fimmu.2019.02933
work_keys_str_mv AT starshinovaannaa sarcoidosisasanautoimmunedisease
AT malkovaannam sarcoidosisasanautoimmunedisease
AT basantsovanataliay sarcoidosisasanautoimmunedisease
AT zinchenkoyulias sarcoidosisasanautoimmunedisease
AT kudryavtsevigorv sarcoidosisasanautoimmunedisease
AT ershovgennadiya sarcoidosisasanautoimmunedisease
AT soprunlidiaa sarcoidosisasanautoimmunedisease
AT mayevskayaveraa sarcoidosisasanautoimmunedisease
AT churilovleonidp sarcoidosisasanautoimmunedisease
AT yablonskiypiotrk sarcoidosisasanautoimmunedisease

Ejemplares similares