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A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells

Glioblastoma is one of the most malignant tumors with very poor prognosis. Glioma stem cells (GSCs) occupy a small proportion in glioma, but they are closely associated with radiotherapy and chemotherapy resistance, promoting tumor angiogenesis, hypoxia response, invasion and recurrence. Therefore,...

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Autores principales: Qi, Shi-Gang, Quan, Li-Qiu, Cui, Xiao-Yue, Li, Hong-Mei, Zhao, Xu-Dong, Li, Rong-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960388/
https://www.ncbi.nlm.nih.gov/pubmed/32002029
http://dx.doi.org/10.3892/ol.2019.11239
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author Qi, Shi-Gang
Quan, Li-Qiu
Cui, Xiao-Yue
Li, Hong-Mei
Zhao, Xu-Dong
Li, Rong-Tao
author_facet Qi, Shi-Gang
Quan, Li-Qiu
Cui, Xiao-Yue
Li, Hong-Mei
Zhao, Xu-Dong
Li, Rong-Tao
author_sort Qi, Shi-Gang
collection PubMed
description Glioblastoma is one of the most malignant tumors with very poor prognosis. Glioma stem cells (GSCs) occupy a small proportion in glioma, but they are closely associated with radiotherapy and chemotherapy resistance, promoting tumor angiogenesis, hypoxia response, invasion and recurrence. Therefore, GSCs have become a new target for tumor treatment and are used in drug screening. Rupesin E is a natural compound obtained from Valeriana jatamansi, and its antitumor activity has not been reported. In the present study, the antitumor activity of rupesin E was investigated, and the results demonstrated that it inhibited the proliferation of GSCs (GSC-3#, GSC-12#, GSC-18#) with the IC(50) values of 7.13±1.41, 13.51±1.46 and 4.44±0.22 µg/ml, respectively. In addition, immunofluorescence cell staining and flow cytometry techniques demonstrated that rupesin E inhibited GSC proliferation and induced apoptosis. Furthermore, rupesin E inhibited the ability of GSC colony formation, indicating its antitumor activity against GSCs in vitro.
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spelling pubmed-69603882020-01-30 A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells Qi, Shi-Gang Quan, Li-Qiu Cui, Xiao-Yue Li, Hong-Mei Zhao, Xu-Dong Li, Rong-Tao Oncol Lett Articles Glioblastoma is one of the most malignant tumors with very poor prognosis. Glioma stem cells (GSCs) occupy a small proportion in glioma, but they are closely associated with radiotherapy and chemotherapy resistance, promoting tumor angiogenesis, hypoxia response, invasion and recurrence. Therefore, GSCs have become a new target for tumor treatment and are used in drug screening. Rupesin E is a natural compound obtained from Valeriana jatamansi, and its antitumor activity has not been reported. In the present study, the antitumor activity of rupesin E was investigated, and the results demonstrated that it inhibited the proliferation of GSCs (GSC-3#, GSC-12#, GSC-18#) with the IC(50) values of 7.13±1.41, 13.51±1.46 and 4.44±0.22 µg/ml, respectively. In addition, immunofluorescence cell staining and flow cytometry techniques demonstrated that rupesin E inhibited GSC proliferation and induced apoptosis. Furthermore, rupesin E inhibited the ability of GSC colony formation, indicating its antitumor activity against GSCs in vitro. D.A. Spandidos 2020-02 2019-12-23 /pmc/articles/PMC6960388/ /pubmed/32002029 http://dx.doi.org/10.3892/ol.2019.11239 Text en Copyright: © Qi et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Qi, Shi-Gang
Quan, Li-Qiu
Cui, Xiao-Yue
Li, Hong-Mei
Zhao, Xu-Dong
Li, Rong-Tao
A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells
title A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells
title_full A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells
title_fullStr A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells
title_full_unstemmed A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells
title_short A natural compound obtained from Valeriana jatamansi selectively inhibits glioma stem cells
title_sort natural compound obtained from valeriana jatamansi selectively inhibits glioma stem cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960388/
https://www.ncbi.nlm.nih.gov/pubmed/32002029
http://dx.doi.org/10.3892/ol.2019.11239
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