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LRRK2 regulates endoplasmic reticulum–mitochondrial tethering through the PERK‐mediated ubiquitination pathway

Mutations in the leucine‐rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson's disease (PD). Impaired mitochondrial function is suspected to play a major role in PD. Nonetheless, the underlying mechanism by which impaired LRRK2 activity contributes to PD pathology...

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Detalles Bibliográficos
Autores principales:	Toyofuku, Toshihiko, Okamoto, Yuki, Ishikawa, Takako, Sasawatari, Shigemi, Kumanogoh, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960452/ https://www.ncbi.nlm.nih.gov/pubmed/31821596 http://dx.doi.org/10.15252/embj.2018100875

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