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Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance
Polyoxazolines are a new promising class of polymers for biomedical applications. Antibiofouling polyoxazoline coatings can suppress bacterial colonization of medical devices, which can cause infections to patients. However, the creation of oxazoline-based films using conventional methods is difficu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960831/ https://www.ncbi.nlm.nih.gov/pubmed/31842276 http://dx.doi.org/10.3390/polym11122069 |
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author | Sťahel, Pavel Mazánková, Věra Tomečková, Klára Matoušková, Petra Brablec, Antonín Prokeš, Lubomír Jurmanová, Jana Buršíková, Vilma Přibyl, Roman Lehocký, Marián Humpolíček, Petr Ozaltin, Kadir Trunec, David |
author_facet | Sťahel, Pavel Mazánková, Věra Tomečková, Klára Matoušková, Petra Brablec, Antonín Prokeš, Lubomír Jurmanová, Jana Buršíková, Vilma Přibyl, Roman Lehocký, Marián Humpolíček, Petr Ozaltin, Kadir Trunec, David |
author_sort | Sťahel, Pavel |
collection | PubMed |
description | Polyoxazolines are a new promising class of polymers for biomedical applications. Antibiofouling polyoxazoline coatings can suppress bacterial colonization of medical devices, which can cause infections to patients. However, the creation of oxazoline-based films using conventional methods is difficult. This study presents a new way to produce plasma polymerized oxazoline-based films with antibiofouling properties and good biocompatibility. The films were created via plasma deposition from 2-methyl-2-oxazoline vapors in nitrogen atmospheric pressure dielectric barrier discharge. Diverse film properties were achieved by increasing the substrate temperature at the deposition. The physical and chemical properties of plasma polymerized polyoxazoline films were studied by SEM, EDX, FTIR, AFM, depth-sensing indentation technique, and surface energy measurement. After tuning of the deposition parameters, films with a capacity to resist bacterial biofilm formation were achieved. Deposited films also promote cell viability. |
format | Online Article Text |
id | pubmed-6960831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69608312020-01-24 Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance Sťahel, Pavel Mazánková, Věra Tomečková, Klára Matoušková, Petra Brablec, Antonín Prokeš, Lubomír Jurmanová, Jana Buršíková, Vilma Přibyl, Roman Lehocký, Marián Humpolíček, Petr Ozaltin, Kadir Trunec, David Polymers (Basel) Article Polyoxazolines are a new promising class of polymers for biomedical applications. Antibiofouling polyoxazoline coatings can suppress bacterial colonization of medical devices, which can cause infections to patients. However, the creation of oxazoline-based films using conventional methods is difficult. This study presents a new way to produce plasma polymerized oxazoline-based films with antibiofouling properties and good biocompatibility. The films were created via plasma deposition from 2-methyl-2-oxazoline vapors in nitrogen atmospheric pressure dielectric barrier discharge. Diverse film properties were achieved by increasing the substrate temperature at the deposition. The physical and chemical properties of plasma polymerized polyoxazoline films were studied by SEM, EDX, FTIR, AFM, depth-sensing indentation technique, and surface energy measurement. After tuning of the deposition parameters, films with a capacity to resist bacterial biofilm formation were achieved. Deposited films also promote cell viability. MDPI 2019-12-12 /pmc/articles/PMC6960831/ /pubmed/31842276 http://dx.doi.org/10.3390/polym11122069 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sťahel, Pavel Mazánková, Věra Tomečková, Klára Matoušková, Petra Brablec, Antonín Prokeš, Lubomír Jurmanová, Jana Buršíková, Vilma Přibyl, Roman Lehocký, Marián Humpolíček, Petr Ozaltin, Kadir Trunec, David Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance |
title | Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance |
title_full | Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance |
title_fullStr | Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance |
title_full_unstemmed | Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance |
title_short | Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance |
title_sort | atmospheric pressure plasma polymerized oxazoline-based thin films—antibacterial properties and cytocompatibility performance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960831/ https://www.ncbi.nlm.nih.gov/pubmed/31842276 http://dx.doi.org/10.3390/polym11122069 |
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