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Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance

Polyoxazolines are a new promising class of polymers for biomedical applications. Antibiofouling polyoxazoline coatings can suppress bacterial colonization of medical devices, which can cause infections to patients. However, the creation of oxazoline-based films using conventional methods is difficu...

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Autores principales: Sťahel, Pavel, Mazánková, Věra, Tomečková, Klára, Matoušková, Petra, Brablec, Antonín, Prokeš, Lubomír, Jurmanová, Jana, Buršíková, Vilma, Přibyl, Roman, Lehocký, Marián, Humpolíček, Petr, Ozaltin, Kadir, Trunec, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960831/
https://www.ncbi.nlm.nih.gov/pubmed/31842276
http://dx.doi.org/10.3390/polym11122069
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author Sťahel, Pavel
Mazánková, Věra
Tomečková, Klára
Matoušková, Petra
Brablec, Antonín
Prokeš, Lubomír
Jurmanová, Jana
Buršíková, Vilma
Přibyl, Roman
Lehocký, Marián
Humpolíček, Petr
Ozaltin, Kadir
Trunec, David
author_facet Sťahel, Pavel
Mazánková, Věra
Tomečková, Klára
Matoušková, Petra
Brablec, Antonín
Prokeš, Lubomír
Jurmanová, Jana
Buršíková, Vilma
Přibyl, Roman
Lehocký, Marián
Humpolíček, Petr
Ozaltin, Kadir
Trunec, David
author_sort Sťahel, Pavel
collection PubMed
description Polyoxazolines are a new promising class of polymers for biomedical applications. Antibiofouling polyoxazoline coatings can suppress bacterial colonization of medical devices, which can cause infections to patients. However, the creation of oxazoline-based films using conventional methods is difficult. This study presents a new way to produce plasma polymerized oxazoline-based films with antibiofouling properties and good biocompatibility. The films were created via plasma deposition from 2-methyl-2-oxazoline vapors in nitrogen atmospheric pressure dielectric barrier discharge. Diverse film properties were achieved by increasing the substrate temperature at the deposition. The physical and chemical properties of plasma polymerized polyoxazoline films were studied by SEM, EDX, FTIR, AFM, depth-sensing indentation technique, and surface energy measurement. After tuning of the deposition parameters, films with a capacity to resist bacterial biofilm formation were achieved. Deposited films also promote cell viability.
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spelling pubmed-69608312020-01-24 Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance Sťahel, Pavel Mazánková, Věra Tomečková, Klára Matoušková, Petra Brablec, Antonín Prokeš, Lubomír Jurmanová, Jana Buršíková, Vilma Přibyl, Roman Lehocký, Marián Humpolíček, Petr Ozaltin, Kadir Trunec, David Polymers (Basel) Article Polyoxazolines are a new promising class of polymers for biomedical applications. Antibiofouling polyoxazoline coatings can suppress bacterial colonization of medical devices, which can cause infections to patients. However, the creation of oxazoline-based films using conventional methods is difficult. This study presents a new way to produce plasma polymerized oxazoline-based films with antibiofouling properties and good biocompatibility. The films were created via plasma deposition from 2-methyl-2-oxazoline vapors in nitrogen atmospheric pressure dielectric barrier discharge. Diverse film properties were achieved by increasing the substrate temperature at the deposition. The physical and chemical properties of plasma polymerized polyoxazoline films were studied by SEM, EDX, FTIR, AFM, depth-sensing indentation technique, and surface energy measurement. After tuning of the deposition parameters, films with a capacity to resist bacterial biofilm formation were achieved. Deposited films also promote cell viability. MDPI 2019-12-12 /pmc/articles/PMC6960831/ /pubmed/31842276 http://dx.doi.org/10.3390/polym11122069 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sťahel, Pavel
Mazánková, Věra
Tomečková, Klára
Matoušková, Petra
Brablec, Antonín
Prokeš, Lubomír
Jurmanová, Jana
Buršíková, Vilma
Přibyl, Roman
Lehocký, Marián
Humpolíček, Petr
Ozaltin, Kadir
Trunec, David
Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance
title Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance
title_full Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance
title_fullStr Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance
title_full_unstemmed Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance
title_short Atmospheric Pressure Plasma Polymerized Oxazoline-Based Thin Films—Antibacterial Properties and Cytocompatibility Performance
title_sort atmospheric pressure plasma polymerized oxazoline-based thin films—antibacterial properties and cytocompatibility performance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960831/
https://www.ncbi.nlm.nih.gov/pubmed/31842276
http://dx.doi.org/10.3390/polym11122069
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