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The effect of ageing on the resolution of inflammation
Ageing is associated with the development of a low-level, systemic, chronic inflammation known as “inflammaging”. This chronic inflammatory state can contribute to diseases of ageing such as sarcopenia and frailty. The presence of inflammaging suggests a failure of the cell clearance mechanisms that...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961112/ https://www.ncbi.nlm.nih.gov/pubmed/31862417 http://dx.doi.org/10.1016/j.arr.2019.101000 |
| Sumario: | Ageing is associated with the development of a low-level, systemic, chronic inflammation known as “inflammaging”. This chronic inflammatory state can contribute to diseases of ageing such as sarcopenia and frailty. The presence of inflammaging suggests a failure of the cell clearance mechanisms that ordinarily aid in the resolution of inflammation after pathogen infiltration or tissue injury. This review aims to explore what is known of how the processes involved in the resolution of inflammation might become defective with age. |
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