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LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence

BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown molecular pathogenesis. Our preliminary microarray analysis revealed the altered expression of lncRNA Cancer Susceptibility Gene 2 (CASC2) in RAS. We therefore analyzed the role of CASC2 in RAS. METHODS: In this st...

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Autores principales: Lu, Jiaping, Zhang, Naizheng, Wu, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961228/
https://www.ncbi.nlm.nih.gov/pubmed/31937279
http://dx.doi.org/10.1186/s12903-019-0993-0
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author Lu, Jiaping
Zhang, Naizheng
Wu, Chen
author_facet Lu, Jiaping
Zhang, Naizheng
Wu, Chen
author_sort Lu, Jiaping
collection PubMed
description BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown molecular pathogenesis. Our preliminary microarray analysis revealed the altered expression of lncRNA Cancer Susceptibility Gene 2 (CASC2) in RAS. We therefore analyzed the role of CASC2 in RAS. METHODS: In this study, plasma samples were obtained from RAS patients and healthy participants. Plasma levels of CASC2 were measured by RT-qPCR. Plasma levels of IL-6 and IL-18 were measured by enzyme-linked immunosorbent assay (ELISA). A follow-up study was performed to analyze the role of CASC2 in the recurrence of RAS. RESULTS: In the present study, we found that lncRNA Cancer Susceptibility Gene 2 (CASC2), as well as pro-inflammatory factors interleukin 6 (IL-6) and interleukin 18 (IL-18), were upregulated in plasma of RAS patients compared with healthy participants. Plasma levels of lncRNA CASC2 were positively correlated with plasma levels of IL-6 and IL-18 in RAS patients but not in healthy participants. Compared with pre-treatment levels, plasma levels of lncRNA CASC2, IL-6 and IL-18 were reduced after recovery. A follow-up study showed that patients with high levels of lncRNA CASC2 had a significantly higher recurrence rate. CONCLUSION: LncRNA CASC 2 is upregulated in RAS and predicts the recurrence.
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spelling pubmed-69612282020-01-17 LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence Lu, Jiaping Zhang, Naizheng Wu, Chen BMC Oral Health Research Article BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral disease with unknown molecular pathogenesis. Our preliminary microarray analysis revealed the altered expression of lncRNA Cancer Susceptibility Gene 2 (CASC2) in RAS. We therefore analyzed the role of CASC2 in RAS. METHODS: In this study, plasma samples were obtained from RAS patients and healthy participants. Plasma levels of CASC2 were measured by RT-qPCR. Plasma levels of IL-6 and IL-18 were measured by enzyme-linked immunosorbent assay (ELISA). A follow-up study was performed to analyze the role of CASC2 in the recurrence of RAS. RESULTS: In the present study, we found that lncRNA Cancer Susceptibility Gene 2 (CASC2), as well as pro-inflammatory factors interleukin 6 (IL-6) and interleukin 18 (IL-18), were upregulated in plasma of RAS patients compared with healthy participants. Plasma levels of lncRNA CASC2 were positively correlated with plasma levels of IL-6 and IL-18 in RAS patients but not in healthy participants. Compared with pre-treatment levels, plasma levels of lncRNA CASC2, IL-6 and IL-18 were reduced after recovery. A follow-up study showed that patients with high levels of lncRNA CASC2 had a significantly higher recurrence rate. CONCLUSION: LncRNA CASC 2 is upregulated in RAS and predicts the recurrence. BioMed Central 2020-01-14 /pmc/articles/PMC6961228/ /pubmed/31937279 http://dx.doi.org/10.1186/s12903-019-0993-0 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lu, Jiaping
Zhang, Naizheng
Wu, Chen
LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence
title LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence
title_full LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence
title_fullStr LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence
title_full_unstemmed LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence
title_short LncRNA CASC 2 is upregulated in aphthous stomatitis and predicts the recurrence
title_sort lncrna casc 2 is upregulated in aphthous stomatitis and predicts the recurrence
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961228/
https://www.ncbi.nlm.nih.gov/pubmed/31937279
http://dx.doi.org/10.1186/s12903-019-0993-0
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