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Automatic construction of metabolic models with enzyme constraints

BACKGROUND: In order to improve the accuracy of constraint-based metabolic models, several approaches have been developed which intend to integrate additional biological information. Two of these methods, MOMENT and GECKO, incorporate enzymatic (kcat) parameters and enzyme mass constraints to furthe...

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Detalles Bibliográficos
Autores principales: Bekiaris, Pavlos Stephanos, Klamt, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961255/
https://www.ncbi.nlm.nih.gov/pubmed/31937255
http://dx.doi.org/10.1186/s12859-019-3329-9