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Association between healthy lifestyle score and breast cancer

BACKGROUND: Majority of earlier studies have assessed the association between individual lifestyle factors and the risk of breast cancer (BC); however, limited information is available linking the whole lifestyle factors to BC. We aimed to examine the association between combined lifestyle score (di...

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Autores principales: Ghosn, Batoul, Benisi-Kohansal, Sanaz, Ebrahimpour-Koujan, Soraiya, Azadbakht, Leila, Esmaillzadeh, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961278/
https://www.ncbi.nlm.nih.gov/pubmed/31937325
http://dx.doi.org/10.1186/s12937-020-0520-9
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author Ghosn, Batoul
Benisi-Kohansal, Sanaz
Ebrahimpour-Koujan, Soraiya
Azadbakht, Leila
Esmaillzadeh, Ahmad
author_facet Ghosn, Batoul
Benisi-Kohansal, Sanaz
Ebrahimpour-Koujan, Soraiya
Azadbakht, Leila
Esmaillzadeh, Ahmad
author_sort Ghosn, Batoul
collection PubMed
description BACKGROUND: Majority of earlier studies have assessed the association between individual lifestyle factors and the risk of breast cancer (BC); however, limited information is available linking the whole lifestyle factors to BC. We aimed to examine the association between combined lifestyle score (diet, physical activity (PA) and smoking) and risk of BC in Iranian population. METHODS: This population-based case-control study included 350 newly diagnosed cases of BC and 700 healthy controls randomly selected from adult women. Dietary intakes, PA and smoking status of study participants were examined using validated questionnaires. The lifestyle risk factors examined in this study included cigarette smoking, physical inactivity, and Healthy Eating Index-2010 (HEI-2010). The lifestyle score ranged from zero (non-healthy) to 3 (most healthy) points. Logistic regression models were fitted to investigate the association between combined lifestyle scores and odds of BC. RESULTS: Mean age and body mass index (BMI) of study participants were 62.4 years and 24.3 kg/m(2), respectively. In the whole study population, individuals with the highest healthy lifestyle score (HLS) were 0.38 times less likely to have BC than those with the lowest score (OR: 0.62; 95% CI: 0.40, 0.93, P(trend) = 0.01). The analysis by menopausal status showed that postmenopausal women with the highest HLS had 44% lower odds of BC compared with those with the lowest score (OR: 0.56; 95% CI: 0.36, 0.88, P (trend) = 0.004). Such association was not seen in premenopausal women. After analyzing each component of HLS, we found that individuals with the highest HEI score were 46% less likely to have BC than those with the lowest score (OR: 0.54; 95% CI: 0.35, 0.82, P(trend) <  0.001). No other significant associations were found between PA and smoking and risk of BC. CONCLUSIONS: Significant inverse associations were found between HLS and HEI with BC especially among postmenopausal women. Prospective studies are required to confirm these findings.
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spelling pubmed-69612782020-01-17 Association between healthy lifestyle score and breast cancer Ghosn, Batoul Benisi-Kohansal, Sanaz Ebrahimpour-Koujan, Soraiya Azadbakht, Leila Esmaillzadeh, Ahmad Nutr J Research BACKGROUND: Majority of earlier studies have assessed the association between individual lifestyle factors and the risk of breast cancer (BC); however, limited information is available linking the whole lifestyle factors to BC. We aimed to examine the association between combined lifestyle score (diet, physical activity (PA) and smoking) and risk of BC in Iranian population. METHODS: This population-based case-control study included 350 newly diagnosed cases of BC and 700 healthy controls randomly selected from adult women. Dietary intakes, PA and smoking status of study participants were examined using validated questionnaires. The lifestyle risk factors examined in this study included cigarette smoking, physical inactivity, and Healthy Eating Index-2010 (HEI-2010). The lifestyle score ranged from zero (non-healthy) to 3 (most healthy) points. Logistic regression models were fitted to investigate the association between combined lifestyle scores and odds of BC. RESULTS: Mean age and body mass index (BMI) of study participants were 62.4 years and 24.3 kg/m(2), respectively. In the whole study population, individuals with the highest healthy lifestyle score (HLS) were 0.38 times less likely to have BC than those with the lowest score (OR: 0.62; 95% CI: 0.40, 0.93, P(trend) = 0.01). The analysis by menopausal status showed that postmenopausal women with the highest HLS had 44% lower odds of BC compared with those with the lowest score (OR: 0.56; 95% CI: 0.36, 0.88, P (trend) = 0.004). Such association was not seen in premenopausal women. After analyzing each component of HLS, we found that individuals with the highest HEI score were 46% less likely to have BC than those with the lowest score (OR: 0.54; 95% CI: 0.35, 0.82, P(trend) <  0.001). No other significant associations were found between PA and smoking and risk of BC. CONCLUSIONS: Significant inverse associations were found between HLS and HEI with BC especially among postmenopausal women. Prospective studies are required to confirm these findings. BioMed Central 2020-01-14 /pmc/articles/PMC6961278/ /pubmed/31937325 http://dx.doi.org/10.1186/s12937-020-0520-9 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ghosn, Batoul
Benisi-Kohansal, Sanaz
Ebrahimpour-Koujan, Soraiya
Azadbakht, Leila
Esmaillzadeh, Ahmad
Association between healthy lifestyle score and breast cancer
title Association between healthy lifestyle score and breast cancer
title_full Association between healthy lifestyle score and breast cancer
title_fullStr Association between healthy lifestyle score and breast cancer
title_full_unstemmed Association between healthy lifestyle score and breast cancer
title_short Association between healthy lifestyle score and breast cancer
title_sort association between healthy lifestyle score and breast cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961278/
https://www.ncbi.nlm.nih.gov/pubmed/31937325
http://dx.doi.org/10.1186/s12937-020-0520-9
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