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HIFI: estimating DNA-DNA interaction frequency from Hi-C data at restriction-fragment resolution
Hi-C is a popular technique to map three-dimensional chromosome conformation. In principle, Hi-C’s resolution is only limited by the size of restriction fragments. However, insufficient sequencing depth forces researchers to artificially reduce the resolution of Hi-C matrices at a loss of biological...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961295/ https://www.ncbi.nlm.nih.gov/pubmed/31937349 http://dx.doi.org/10.1186/s13059-019-1913-y |