DENDRO: genetic heterogeneity profiling and subclone detection by single-cell RNA sequencing

Although scRNA-seq is now ubiquitously adopted in studies of intratumor heterogeneity, detection of somatic mutations and inference of clonal membership from scRNA-seq is currently unreliable. We propose DENDRO, an analysis method for scRNA-seq data that clusters single cells into genetically distin...

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Detalles Bibliográficos
Autores principales: Zhou, Zilu, Xu, Bihui, Minn, Andy, Zhang, Nancy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961311/
https://www.ncbi.nlm.nih.gov/pubmed/31937348
http://dx.doi.org/10.1186/s13059-019-1922-x

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