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Maternal age and educational level modify the association between chronic hepatitis B infection and preterm labor
BACKGROUND: Few studies have investigated whether maternal age and education level modify the association of chronic hepatitis B virus (HBV) infection with preterm labor. We hypothesized that the association of HBV infection with preterm labor is modified by maternal age and education level. METHODS...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961340/ https://www.ncbi.nlm.nih.gov/pubmed/31937269 http://dx.doi.org/10.1186/s12884-020-2729-1 |
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author | Peng, Songxu Chen, Hongyan Li, Xiu Du, Yukai Gan, Yong |
author_facet | Peng, Songxu Chen, Hongyan Li, Xiu Du, Yukai Gan, Yong |
author_sort | Peng, Songxu |
collection | PubMed |
description | BACKGROUND: Few studies have investigated whether maternal age and education level modify the association of chronic hepatitis B virus (HBV) infection with preterm labor. We hypothesized that the association of HBV infection with preterm labor is modified by maternal age and education level. METHODS: A retrospective cohort study was conducted on the HBsAg-positive and HBsAg-negative pregnant women delivered from June 2012 to August 2017 at Wuhan Medical Care Center for Women and Children, Wuhan, China. A multivariate regression model was used in this study. RESULTS: This study included 2050 HBsAg-positive pregnant women and 2050 HBsAg negative women. In the stratified analyses, positive HBsAg status was associated with the increased risk of preterm labor in women aged < 30 years, having low educational level, with an odds ratio of 1.65(95% CI 1.07–2.54) and 2.59(95% CI 1.41–4.76), respectively. Breslow-Day test showed that there existed significant differences in the ORs for HBsAg carriage across each stratum of maternal age (p = 0.023), educational level (p = 0.002). After adjusting other co-variables, we observed maternal HBV infection (OR 1.60, 95% CI 1.03–2.49) was still associated with risk of preterm labor in pregnancy women with age < 30. Similarly, the significant association of HBV infection (OR 2.49, 95% CI 1.34–4.63) with preterm labor remained in low educated women. CONCLUSIONS: Our results indicated that HBV infection was associated with high risk of preterm labor, but maternal age and educational level could modify the association between HBV infection and preterm labor. |
format | Online Article Text |
id | pubmed-6961340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69613402020-01-17 Maternal age and educational level modify the association between chronic hepatitis B infection and preterm labor Peng, Songxu Chen, Hongyan Li, Xiu Du, Yukai Gan, Yong BMC Pregnancy Childbirth Research Article BACKGROUND: Few studies have investigated whether maternal age and education level modify the association of chronic hepatitis B virus (HBV) infection with preterm labor. We hypothesized that the association of HBV infection with preterm labor is modified by maternal age and education level. METHODS: A retrospective cohort study was conducted on the HBsAg-positive and HBsAg-negative pregnant women delivered from June 2012 to August 2017 at Wuhan Medical Care Center for Women and Children, Wuhan, China. A multivariate regression model was used in this study. RESULTS: This study included 2050 HBsAg-positive pregnant women and 2050 HBsAg negative women. In the stratified analyses, positive HBsAg status was associated with the increased risk of preterm labor in women aged < 30 years, having low educational level, with an odds ratio of 1.65(95% CI 1.07–2.54) and 2.59(95% CI 1.41–4.76), respectively. Breslow-Day test showed that there existed significant differences in the ORs for HBsAg carriage across each stratum of maternal age (p = 0.023), educational level (p = 0.002). After adjusting other co-variables, we observed maternal HBV infection (OR 1.60, 95% CI 1.03–2.49) was still associated with risk of preterm labor in pregnancy women with age < 30. Similarly, the significant association of HBV infection (OR 2.49, 95% CI 1.34–4.63) with preterm labor remained in low educated women. CONCLUSIONS: Our results indicated that HBV infection was associated with high risk of preterm labor, but maternal age and educational level could modify the association between HBV infection and preterm labor. BioMed Central 2020-01-14 /pmc/articles/PMC6961340/ /pubmed/31937269 http://dx.doi.org/10.1186/s12884-020-2729-1 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Peng, Songxu Chen, Hongyan Li, Xiu Du, Yukai Gan, Yong Maternal age and educational level modify the association between chronic hepatitis B infection and preterm labor |
title | Maternal age and educational level modify the association between chronic hepatitis B infection and preterm labor |
title_full | Maternal age and educational level modify the association between chronic hepatitis B infection and preterm labor |
title_fullStr | Maternal age and educational level modify the association between chronic hepatitis B infection and preterm labor |
title_full_unstemmed | Maternal age and educational level modify the association between chronic hepatitis B infection and preterm labor |
title_short | Maternal age and educational level modify the association between chronic hepatitis B infection and preterm labor |
title_sort | maternal age and educational level modify the association between chronic hepatitis b infection and preterm labor |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961340/ https://www.ncbi.nlm.nih.gov/pubmed/31937269 http://dx.doi.org/10.1186/s12884-020-2729-1 |
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