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Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships
ABSTRACT: This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li[Formula: see text] O by the sol–gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961499/ https://www.ncbi.nlm.nih.gov/pubmed/32009741 http://dx.doi.org/10.1007/s10971-016-4097-x |
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author | Maçon, Anthony L. B. Jacquemin, Manon Page, Samuel J. Li, Siwei Bertazzo, Sergio Stevens, Molly M. Hanna, John V. Jones, Julian R. |
author_facet | Maçon, Anthony L. B. Jacquemin, Manon Page, Samuel J. Li, Siwei Bertazzo, Sergio Stevens, Molly M. Hanna, John V. Jones, Julian R. |
author_sort | Maçon, Anthony L. B. |
collection | PubMed |
description | ABSTRACT: This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li[Formula: see text] O by the sol–gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol–gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, [Formula: see text] Si and [Formula: see text] Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-6961499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-69614992020-01-29 Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships Maçon, Anthony L. B. Jacquemin, Manon Page, Samuel J. Li, Siwei Bertazzo, Sergio Stevens, Molly M. Hanna, John V. Jones, Julian R. J Solgel Sci Technol Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications ABSTRACT: This work reports the synthesis of lithium-silicate glass, containing 10 mol% of Li[Formula: see text] O by the sol–gel process, intended for the regeneration of cartilage. Lithium citrate and lithium nitrate were selected as lithium precursors. The effects of the lithium precursor on the sol–gel process, and the resulting glass structure, morphology, dissolution behaviour, chondrocyte viability and proliferation, were investigated. When lithium citrate was used, mesoporous glass containing lithium as a network modifier was obtained, whereas the use of lithium nitrate produced relatively dense glass-ceramic with the presence of lithium metasilicate, as shown by X-ray diffraction, [Formula: see text] Si and [Formula: see text] Li MAS NMR and nitrogen sorption data. Nitrate has a better affinity for lithium than citrate, leading to heterogeneous crystallisation from the mesopores, where lithium salts precipitated during drying. Citrate decomposed at a lower temperature, where the crystallisation of lithium-silicate crystal is not thermodynamically favourable. Upon decomposition of the citrate, a solid-state salt metathesis reaction between citrate and silanol occurred, followed by the diffusion of lithium within the structure of the glass. Both glass and glass-ceramic released silica and lithium ions in culture media, but release rate was lower for the glass-ceramic. Both samples did not affect chondrocyte viability and proliferation. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2016-06-23 2017 /pmc/articles/PMC6961499/ /pubmed/32009741 http://dx.doi.org/10.1007/s10971-016-4097-x Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Raw data available on request from julian.r.jones@imperial.ac.uk. |
spellingShingle | Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications Maçon, Anthony L. B. Jacquemin, Manon Page, Samuel J. Li, Siwei Bertazzo, Sergio Stevens, Molly M. Hanna, John V. Jones, Julian R. Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships |
title | Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships |
title_full | Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships |
title_fullStr | Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships |
title_full_unstemmed | Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships |
title_short | Lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships |
title_sort | lithium-silicate sol–gel bioactive glass and the effect of lithium precursor on structure–property relationships |
topic | Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961499/ https://www.ncbi.nlm.nih.gov/pubmed/32009741 http://dx.doi.org/10.1007/s10971-016-4097-x |
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