Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation

Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required...

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Detalles Bibliográficos
Autores principales: Jacomin, Anne-Claire, Nezis, Ioannis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961681/
https://www.ncbi.nlm.nih.gov/pubmed/31993495
http://dx.doi.org/10.1080/23723556.2019.1682309
Descripción
Sumario:Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required for the degradation of the I-kappa B kinase complex. This regulatory mechanism is essential for the downregulation of the immune deficiency (IMD) pathway in response to commensal microbiota to prevent inflammation.

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