Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation

Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required...

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Autores principales: Jacomin, Anne-Claire, Nezis, Ioannis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961681/
https://www.ncbi.nlm.nih.gov/pubmed/31993495
http://dx.doi.org/10.1080/23723556.2019.1682309
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author Jacomin, Anne-Claire
Nezis, Ioannis P.
author_facet Jacomin, Anne-Claire
Nezis, Ioannis P.
author_sort Jacomin, Anne-Claire
collection PubMed
description Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required for the degradation of the I-kappa B kinase complex. This regulatory mechanism is essential for the downregulation of the immune deficiency (IMD) pathway in response to commensal microbiota to prevent inflammation.
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spelling pubmed-69616812020-09-28 Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation Jacomin, Anne-Claire Nezis, Ioannis P. Mol Cell Oncol Commentary Implication of autophagy in the downregulation of immune signaling pathways through the degradation of their components constitutes an emerging field of investigation. Our work showed that the selective interaction of Drosophila protein Kenny/IKKγ (CG16910) with the autophagic machinery is required for the degradation of the I-kappa B kinase complex. This regulatory mechanism is essential for the downregulation of the immune deficiency (IMD) pathway in response to commensal microbiota to prevent inflammation. Taylor & Francis 2019-11-06 /pmc/articles/PMC6961681/ /pubmed/31993495 http://dx.doi.org/10.1080/23723556.2019.1682309 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Jacomin, Anne-Claire
Nezis, Ioannis P.
Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
title Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
title_full Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
title_fullStr Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
title_full_unstemmed Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
title_short Selective autophagic degradation of the IKK complex in Drosophila is mediated by Kenny/IKKγ to control inflammation
title_sort selective autophagic degradation of the ikk complex in drosophila is mediated by kenny/ikkγ to control inflammation
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961681/
https://www.ncbi.nlm.nih.gov/pubmed/31993495
http://dx.doi.org/10.1080/23723556.2019.1682309
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AT nezisioannisp selectiveautophagicdegradationoftheikkcomplexindrosophilaismediatedbykennyikkgtocontrolinflammation

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