Cargando…

Metformin promotes innate immunity through a conserved PMK-1/p38 MAPK pathway

Metformin, as the first-line oral drug for type 2 diabetes, has proven benefits against aging, cancer and cardiovascular diseases. But the influence of metformin to the immune response and its molecular mechanisms remain obscure. Metformin increases resistance to not only the Gram-negative pathogens...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Yi, Liu, Fang, Li, Sanhua, Jiang, Nian, Yu, Changyan, Zhu, Xinting, Qin, Ying, Hui, Jing, Meng, Lingjie, Song, Changwei, Li, Xiao-Fei, Liu, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961722/ https://www.ncbi.nlm.nih.gov/pubmed/31851866 http://dx.doi.org/10.1080/21505594.2019.1706305

Ejemplares similares

Sanguinarine promotes healthspan and innate immunity through a conserved mechanism of ROS-mediated PMK-1/SKN-1 activation
por: Liu, Fang, et al.
Publicado: (2022)

Phosphorylation of the Conserved Transcription Factor ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in Caenorhabditis elegans
por: Shivers, Robert P., et al.
Publicado: (2010)

Metformin induces S‐adenosylmethionine restriction to extend the Caenorhabditis elegans healthspan through H3K4me3 modifiers
por: Xiao, Yi, et al.
Publicado: (2022)

Dioscin integrates regulation of monosaturated fatty acid metabolism to extend the life span through XBP-1/SBP-1 dependent manner
por: Xiao, Yi, et al.
Publicado: (2023)

The Ubiquitin Ligase RPM-1 and the p38 MAPK PMK-3 Regulate AMPA Receptor Trafficking
por: Park, Eun Chan, et al.
Publicado: (2009)

The p38 MAPK/PMK-1 Pathway Is Required for Resistance to Nocardia farcinica Infection in Caenorhabditis elegance
por: Yang, Ruiqiu, et al.
Publicado: (2022)

Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans
por: Pagano, Daniel J., et al.
Publicado: (2015)

Correction: Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans
Publicado: (2015)

Autophagy-related genes genetically interact with Pmk1 MAPK signaling in fission yeast
por: Takasaki, Teruaki, et al.
Publicado: (2022)

Role of GATA transcription factor ELT-2 and p38 MAPK PMK-1 in recovery from acute P. aeruginosa infection in C. elegans
por: Head, Brian P., et al.
Publicado: (2016)

Final report on the PMK-2 projects
por: Szabados, L, et al.
Publicado: (2009)

PMK-1 p38 MAPK promotes cadmium stress resistance, the expression of SKN-1/Nrf and DAF-16 target genes, and protein biosynthesis in Caenorhabditis elegans
por: Keshet, Alex, et al.
Publicado: (2017)

Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy
por: Soltanmohammadi, Najmeh, et al.
Publicado: (2022)

Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1
por: Matilainen, Olli, et al.
Publicado: (2021)

PoRal2 Is Involved in Appressorium Formation and Virulence via Pmk1 MAPK Pathways in the Rice Blast Fungus Pyricularia oryzae
por: Qu, Yingmin, et al.
Publicado: (2021)

Usnic Acid extends healthspan and improves the neurodegeneration diseases via mTOR/PHA-4 signaling pathway in Caenorhabditis elegans
por: Xiao, Yi, et al.
Publicado: (2022)

Author Correction: Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy
por: Soltanmohammadi, Najmeh, et al.
Publicado: (2023)

Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner
por: Xia, Wenjiao, et al.
Publicado: (2021)

PMK—A Knowledge Processing Framework for Autonomous Robotics Perception and Manipulation
por: Diab, Mohammed, et al.
Publicado: (2019)

Neospora caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity
por: Mota, Caroline M., et al.
Publicado: (2016)

Metformin inhibits testosterone-induced endoplasmic reticulum stress in ovarian granulosa cells via inactivation of p38 MAPK
por: Jin, Jiamin, et al.
Publicado: (2020)

Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats
por: Choi, Yoon Jeong, et al.
Publicado: (2016)

The Specific Capsule Depolymerase of Phage PMK34 Sensitizes Acinetobacter baumannii to Serum Killing
por: Abdelkader, Karim, et al.
Publicado: (2022)

Phosphoproteomic and Metabolomic Profiling Uncovers the Roles of CcPmk1 in the Pathogenicity of Cytospora chrysosperma
por: Yu, Lu, et al.
Publicado: (2022)

Robust process capability indices C(pm) and C(pmk) using Weibull process
por: Kashif, Muhammad, et al.
Publicado: (2023)

Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin-resistant ovarian cancer
por: XIE, YA, et al.
Publicado: (2014)

RIOK-1 Is a Suppressor of the p38 MAPK Innate Immune Pathway in Caenorhabditis elegans
por: Chen, Yi-Wei, et al.
Publicado: (2018)

Corrigendum: Neospora Caninum Activates p38 MAPK as an Evasion Mechanism against Innate Immunity
por: Mota, Caroline M., et al.
Publicado: (2019)

Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability
por: Wang, Tiantian, et al.
Publicado: (2020)

Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1
por: Ling, Sunbin, et al.
Publicado: (2017)

The MAP Kinase CfPMK1 Is a Key Regulator of Pathogenesis, Development, and Stress Tolerance of Colletotrichum fructicola
por: Liang, Xiaofei, et al.
Publicado: (2019)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis
por: Li, Bo, et al.
Publicado: (2019)

Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway
por: Chen, Lihui, et al.
Publicado: (2023)

PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach
por: Choi, Yoon Jeong, et al.
Publicado: (2016)

Mitogen-Activated Protein Kinase CsPMK1 Is Essential for Pepper Fruit Anthracnose by Colletotrichum scovillei
por: Fu, Teng, et al.
Publicado: (2022)

Knockdown of Wip1 Enhances Sensitivity to Radiation in HeLa Cells Through Activation of p38 MAPK
por: Wang, Hong-yong, et al.
Publicado: (2015)

Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection
por: Wang, Bo, et al.
Publicado: (2015)

BMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway
por: Yu, Jun, et al.
Publicado: (2021)

All-trans retinoic acid restored the osteogenic ability of BMP9 in osteosarcoma through the p38 MAPK pathway
por: Wu, Nian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_54r2la0naic8l34oj0begc9hvo