Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in C. elegans

Statins belong to the most pre-scribed cholesterol lowering drugs in western countries. Their competitive inhibition of the HMG-CoA reductase causes a reduction in the mevalonate pool, resulting in reduced cholesterol biosynthesis, impaired protein prenylation and glycosylation. Recently, a cohort s...

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Detalles Bibliográficos
Autores principales: Jahn, Andreas, Scherer, Bo, Fritz, Gerhard, Honnen, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2020
Materias:
Orginal Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961767/
https://www.ncbi.nlm.nih.gov/pubmed/32010481
http://dx.doi.org/10.14336/AD.2019.0416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961767/
https://www.ncbi.nlm.nih.gov/pubmed/32010481
http://dx.doi.org/10.14336/AD.2019.0416

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