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The Paradoxical Effect of Deep Brain Stimulation on Memory
Deep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum—dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive me...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961776/ https://www.ncbi.nlm.nih.gov/pubmed/32010491 http://dx.doi.org/10.14336/AD.2019.0511 |
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author | Tan, Shawn Zheng Kai Fung, Man-Lung Koh, Junhao Chan, Ying-Shing Lim, Lee Wei |
author_facet | Tan, Shawn Zheng Kai Fung, Man-Lung Koh, Junhao Chan, Ying-Shing Lim, Lee Wei |
author_sort | Tan, Shawn Zheng Kai |
collection | PubMed |
description | Deep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum—dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive memory. In this review, the key hypotheses on how DBS affects memory are highlighted. We consolidate the findings and conclusions from the current research on the effects of DBS on memory in attempt to make sense of the bidirectional nature of DBS in disrupting and enhancing memory. Based on the current literature, we hypothesize that the timing of DBS plays a key role in its contradictory effects, and therefore, we propose a consolidated model of how DBS can both disrupt and enhance memory. |
format | Online Article Text |
id | pubmed-6961776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-69617762020-02-01 The Paradoxical Effect of Deep Brain Stimulation on Memory Tan, Shawn Zheng Kai Fung, Man-Lung Koh, Junhao Chan, Ying-Shing Lim, Lee Wei Aging Dis Review Article Deep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum—dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive memory. In this review, the key hypotheses on how DBS affects memory are highlighted. We consolidate the findings and conclusions from the current research on the effects of DBS on memory in attempt to make sense of the bidirectional nature of DBS in disrupting and enhancing memory. Based on the current literature, we hypothesize that the timing of DBS plays a key role in its contradictory effects, and therefore, we propose a consolidated model of how DBS can both disrupt and enhance memory. JKL International LLC 2020-02-01 /pmc/articles/PMC6961776/ /pubmed/32010491 http://dx.doi.org/10.14336/AD.2019.0511 Text en Copyright: © 2019 Tan et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Review Article Tan, Shawn Zheng Kai Fung, Man-Lung Koh, Junhao Chan, Ying-Shing Lim, Lee Wei The Paradoxical Effect of Deep Brain Stimulation on Memory |
title | The Paradoxical Effect of Deep Brain Stimulation on Memory |
title_full | The Paradoxical Effect of Deep Brain Stimulation on Memory |
title_fullStr | The Paradoxical Effect of Deep Brain Stimulation on Memory |
title_full_unstemmed | The Paradoxical Effect of Deep Brain Stimulation on Memory |
title_short | The Paradoxical Effect of Deep Brain Stimulation on Memory |
title_sort | paradoxical effect of deep brain stimulation on memory |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961776/ https://www.ncbi.nlm.nih.gov/pubmed/32010491 http://dx.doi.org/10.14336/AD.2019.0511 |
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