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ER stress and Rho kinase activation underlie the vasculopathy of CADASIL

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) leads to premature stroke and vascular dementia. Mechanism-specific therapies for this aggressive cerebral small vessel disease are lacking. CADASIL is caused by NOTCH3 mutations that influence vascu...

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Detalles Bibliográficos
Autores principales:	Neves, Karla B., Harvey, Adam P., Moreton, Fiona, Montezano, Augusto C., Rios, Francisco J., Alves-Lopes, Rhéure, Nguyen Dinh Cat, Aurelie, Rocchicciolli, Paul, Delles, Christian, Joutel, Anne, Muir, Keith, Touyz, Rhian M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962020/ https://www.ncbi.nlm.nih.gov/pubmed/31647781 http://dx.doi.org/10.1172/jci.insight.131344

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