Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists

Aryl hydrocarbon receptor (AHR) is an essential regulator of gut immunity and a promising therapeutic target for inflammatory bowel disease (IBD). Current AHR agonists are inadequate for clinical translation due to low activity, inadequate pharmacokinetics, or toxicity. We synthesized a structurally...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Jiaxuan, Haller, Carolyn A., Jernigan, Finith E., Koerner, Steffi K., Wong, Daniel J., Wang, Yiqiang, Cheong, Jae Eun, Kosaraju, Revanth, Kwan, Julian, Park, Diane D., Thomas, Beena, Bhasin, Swati, De La Rosa, Roberto C., Premji, Alykhan M., Liu, Liying, Park, Eden, Moss, Alan C., Emili, Andrew, Bhasin, Manoj, Sun, Lijun, Chaikof, Elliot L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962035/
https://www.ncbi.nlm.nih.gov/pubmed/31998845
http://dx.doi.org/10.1126/sciadv.aay8230

Ejemplares similares

Ejemplares similares