ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942

The CDK7 inhibitors (CDK7i) ICEC0942 and THZ1, are promising new cancer therapeutics. Resistance to targeted drugs frequently compromises cancer treatment. We sought to identify mechanisms by which cancer cells may become resistant to CDK7i. Resistant lines were established through continuous drug s...

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Detalles Bibliográficos
Autores principales: Sava, Georgina P., Fan, Hailing, Fisher, Rosemary A., Lusvarghi, Sabrina, Pancholi, Sunil, Ambudkar, Suresh V., Martin, Lesley-Ann, Charles Coombes, R., Buluwela, Lakjaya, Ali, Simak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962093/
https://www.ncbi.nlm.nih.gov/pubmed/31530935
http://dx.doi.org/10.1038/s41388-019-1008-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962093/
https://www.ncbi.nlm.nih.gov/pubmed/31530935
http://dx.doi.org/10.1038/s41388-019-1008-y

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