AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation

Patients with stage II or III colorectal cancer (CRC) exhibit various clinical outcomes after radical treatments. The 5-year survival rate was between 50 and 87%. However, the underlying mechanisms of the variation remain unclear. Here we show that AMPKα1 is overexpressed in CRC patient specimens an...

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Detalles Bibliográficos
Autores principales: Wang, Ying-Nan, Lu, Yun-Xin, Liu, Jie, Jin, Ying, Bi, Hui-Chang, Zhao, Qi, Liu, Ze-Xian, Li, Ying-Qin, Hu, Jia-Jia, Sheng, Hui, Jiang, Yi-Ming, Zhang, Chao, Tian, Feng, Chen, Yang, Pan, Zhi-Zhong, Chen, Gong, Zeng, Zhao-Lei, Liu, Kai-Yan, Ogasawara, Marcia, Yun, Jin-Ping, Ju, Huai-Qiang, Feng, Jian-Xiong, Xie, Dan, Gao, Song, Jia, Wei-Hua, Kopetz, Scott, Xu, Rui-Hua, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962094/
https://www.ncbi.nlm.nih.gov/pubmed/31530934
http://dx.doi.org/10.1038/s41388-019-1004-2

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