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Targeting the TR4 nuclear receptor-mediated lncTASR/AXL signaling with tretinoin increases the sunitinib sensitivity to better suppress the RCC progression

Renal cell carcinoma (RCC) is one of the most lethal urological tumors. Using sunitinib to improve the survival has become the first-line therapy for metastatic RCC patients. However, the occurrence of sunitinib resistance in the clinical application has curtailed its efficacy. Here we found TR4 nuc...

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Detalles Bibliográficos
Autores principales:	Shi, Hangchuan, Sun, Yin, He, Miao, Yang, Xiong, Hamada, Michiaki, Fukunaga, Tsukasa, Zhang, Xiaoping, Chang, Chawnshang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962095/ https://www.ncbi.nlm.nih.gov/pubmed/31501521 http://dx.doi.org/10.1038/s41388-019-0962-8

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