Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells

Foam cells are specialized lipid-loaded macrophages derived from monocytes and are a key pathological feature of atherosclerotic lesions. Lysophosphatidylcholine (LPC) is a major lipid component of the plasma membrane with a broad spectrum of proinflammatory activities and plays a key role in athero...

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Detalles Bibliográficos
Autores principales: Corrêa, Rafael, Silva, Luís Felipe Fonseca, Ribeiro, Dalila Juliana Silva, Almeida, Raquel das Neves, Santos, Igor de Oliveira, Corrêa, Luís Henrique, de Sant'Ana, Lívia Pimentel, Assunção, Leonardo Santos, Bozza, Patrícia T., Magalhães, Kelly Grace
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962110/
https://www.ncbi.nlm.nih.gov/pubmed/31998284
http://dx.doi.org/10.3389/fimmu.2019.02927

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