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Retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension

We here studied the clinical features, cardiac structure, and functional changes and prognosis of hypertrophic cardiomyopathy (HCM) patients with hypertension (HTN). A total of 90 HCM patients with HTN and 172 patients without HTN were divided into a hypertensive group and non-hypertensive group. Th...

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Autores principales: Luo, Qin, Chen, Jin, Zhang, Tianhua, Tang, Xiaoyu, Yu, Bilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962215/
https://www.ncbi.nlm.nih.gov/pubmed/31941943
http://dx.doi.org/10.1038/s41598-019-57230-z
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author Luo, Qin
Chen, Jin
Zhang, Tianhua
Tang, Xiaoyu
Yu, Bilian
author_facet Luo, Qin
Chen, Jin
Zhang, Tianhua
Tang, Xiaoyu
Yu, Bilian
author_sort Luo, Qin
collection PubMed
description We here studied the clinical features, cardiac structure, and functional changes and prognosis of hypertrophic cardiomyopathy (HCM) patients with hypertension (HTN). A total of 90 HCM patients with HTN and 172 patients without HTN were divided into a hypertensive group and non-hypertensive group. The clinical characteristics, cardiac structure and function, and prognosis of the two groups were compared. Our study found that HCM patients with HTN had fewer syncope events in their medical histories (8% vs. 22%, P < 0.01) and sudden deaths in the family (3% vs. 10%, P < 0.05). The prevalence of apical hypertrophy (18% vs. 7%, P < 0.01) and midventricular obstruction (26% vs. 15%, P < 0.05) was higher in the HTN group. Besides, simple HCM patients had more pathogenic gene mutations, while those with HTN were more likely to have mutations of uncertain clinical significance (64% vs. 24%, P < 0.05). Evaluation of 5-year survival rate showed a trend for a worse prognosis in HCM patients with HTN, but the results were not statistically insignificant (P = 0.065). In conclusion, we found that the clinical phenotypes of HCM patients with HTN differed from those of patients with HCM alone, suggesting that HTN may play a pathogenic role in the pathogenesis of hypertensive hypertrophic cardiomyopathy patients.
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spelling pubmed-69622152020-01-23 Retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension Luo, Qin Chen, Jin Zhang, Tianhua Tang, Xiaoyu Yu, Bilian Sci Rep Article We here studied the clinical features, cardiac structure, and functional changes and prognosis of hypertrophic cardiomyopathy (HCM) patients with hypertension (HTN). A total of 90 HCM patients with HTN and 172 patients without HTN were divided into a hypertensive group and non-hypertensive group. The clinical characteristics, cardiac structure and function, and prognosis of the two groups were compared. Our study found that HCM patients with HTN had fewer syncope events in their medical histories (8% vs. 22%, P < 0.01) and sudden deaths in the family (3% vs. 10%, P < 0.05). The prevalence of apical hypertrophy (18% vs. 7%, P < 0.01) and midventricular obstruction (26% vs. 15%, P < 0.05) was higher in the HTN group. Besides, simple HCM patients had more pathogenic gene mutations, while those with HTN were more likely to have mutations of uncertain clinical significance (64% vs. 24%, P < 0.05). Evaluation of 5-year survival rate showed a trend for a worse prognosis in HCM patients with HTN, but the results were not statistically insignificant (P = 0.065). In conclusion, we found that the clinical phenotypes of HCM patients with HTN differed from those of patients with HCM alone, suggesting that HTN may play a pathogenic role in the pathogenesis of hypertensive hypertrophic cardiomyopathy patients. Nature Publishing Group UK 2020-01-15 /pmc/articles/PMC6962215/ /pubmed/31941943 http://dx.doi.org/10.1038/s41598-019-57230-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Luo, Qin
Chen, Jin
Zhang, Tianhua
Tang, Xiaoyu
Yu, Bilian
Retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension
title Retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension
title_full Retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension
title_fullStr Retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension
title_full_unstemmed Retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension
title_short Retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension
title_sort retrospective analysis of clinical phenotype and prognosis of hypertrophic cardiomyopathy complicated with hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962215/
https://www.ncbi.nlm.nih.gov/pubmed/31941943
http://dx.doi.org/10.1038/s41598-019-57230-z
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