Discovery of tumoricidal DNA oligonucleotides by response-directed in vitro evolution

Drug discovery is challenged by ineffectiveness of drugs against variable and evolving diseases, and adverse effects due to poor selectivity. We describe a robust platform which potentially addresses these limitations. The platform enables rapid discovery of DNA oligonucleotides evolved in vitro for...

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Detalles Bibliográficos
Autores principales: Mamet, Noam, Amir, Yaniv, Lavi, Erez, Bassali, Liron, Harari, Gil, Rusinek, Itai, Skalka, Nir, Debby, Elinor, Greenberg, Mor, Zamir, Adva, Paz, Anastasia, Reiss, Neria, Loewenthal, Gil, Avivi, Irit, Shimoni, Avichai, Neev, Guy, Abu-Horowitz, Almogit, Bachelet, Ido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962221/
https://www.ncbi.nlm.nih.gov/pubmed/31941992
http://dx.doi.org/10.1038/s42003-020-0756-0

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