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Syndecan-3 in Inflammation and Angiogenesis

Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null mice grow and develop normally, all be it wit...

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Autores principales: Arokiasamy, Samantha, Balderstone, Michaela J. M., De Rossi, Giulia, Whiteford, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962229/
https://www.ncbi.nlm.nih.gov/pubmed/31998313
http://dx.doi.org/10.3389/fimmu.2019.03031
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author Arokiasamy, Samantha
Balderstone, Michaela J. M.
De Rossi, Giulia
Whiteford, James R.
author_facet Arokiasamy, Samantha
Balderstone, Michaela J. M.
De Rossi, Giulia
Whiteford, James R.
author_sort Arokiasamy, Samantha
collection PubMed
description Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null mice grow and develop normally, all be it with subtle anatomical phenotypes in the brain. Roles for this molecule in both neuronal and brain tissue have been identified, and is associated with altered satiety responses. Recent studies suggest that SDC3 expression is not restricted to neuronal tissues and has important roles in inflammatory disorders such as rheumatoid arthritis, disease associated processes such as angiogenesis and in the facilitation of infection of dendritic cells by HIV. The purpose of this review article is to explore these new biological insights into SDC3 functions in inflammatory disease.
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spelling pubmed-69622292020-01-29 Syndecan-3 in Inflammation and Angiogenesis Arokiasamy, Samantha Balderstone, Michaela J. M. De Rossi, Giulia Whiteford, James R. Front Immunol Immunology Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null mice grow and develop normally, all be it with subtle anatomical phenotypes in the brain. Roles for this molecule in both neuronal and brain tissue have been identified, and is associated with altered satiety responses. Recent studies suggest that SDC3 expression is not restricted to neuronal tissues and has important roles in inflammatory disorders such as rheumatoid arthritis, disease associated processes such as angiogenesis and in the facilitation of infection of dendritic cells by HIV. The purpose of this review article is to explore these new biological insights into SDC3 functions in inflammatory disease. Frontiers Media S.A. 2020-01-09 /pmc/articles/PMC6962229/ /pubmed/31998313 http://dx.doi.org/10.3389/fimmu.2019.03031 Text en Copyright © 2020 Arokiasamy, Balderstone, De Rossi and Whiteford. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Arokiasamy, Samantha
Balderstone, Michaela J. M.
De Rossi, Giulia
Whiteford, James R.
Syndecan-3 in Inflammation and Angiogenesis
title Syndecan-3 in Inflammation and Angiogenesis
title_full Syndecan-3 in Inflammation and Angiogenesis
title_fullStr Syndecan-3 in Inflammation and Angiogenesis
title_full_unstemmed Syndecan-3 in Inflammation and Angiogenesis
title_short Syndecan-3 in Inflammation and Angiogenesis
title_sort syndecan-3 in inflammation and angiogenesis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962229/
https://www.ncbi.nlm.nih.gov/pubmed/31998313
http://dx.doi.org/10.3389/fimmu.2019.03031
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