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Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor

The structural plasticity of G-protein coupled receptors (GPCRs) enables the long-range transmission of conformational changes induced by specific orthosteric site ligands and other pleiotropic factors. Here, we demonstrate that the ligand binding cavity in the sphingosine 1-phosphate receptor S1PR1...

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Detalles Bibliográficos
Autores principales:	Patrone, Marco, Cammarota, Eugenia, Berno, Valeria, Tornaghi, Paola, Mazza, Davide, Degano, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962373/ https://www.ncbi.nlm.nih.gov/pubmed/31941999 http://dx.doi.org/10.1038/s42003-020-0752-4

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