Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment

Altered metabolism in pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs) contributes to the pathology of pulmonary hypertension (PH), but changes in substrate uptake and how substrates are utilized have not been fully characterized. We hypothesized stable isotope metabolomic...

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Detalles Bibliográficos
Autores principales: Hernandez-Saavedra, Daniel, Sanders, Linda, Freeman, Scott, Reisz, Julie A., Lee, Michael H., Mickael, Claudia, Kumar, Rahul, Kassa, Biruk, Gu, Sue, Alessandro, Angelo D’, Stenmark, Kurt R., Tuder, Rubin M., Graham, Brian B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962446/
https://www.ncbi.nlm.nih.gov/pubmed/31942023
http://dx.doi.org/10.1038/s41598-019-57200-5

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