iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity

The ex vivo production of platelets depleted of human leukocyte antigen class I (HLA-I) could serve as a universal measure to overcome platelet transfusion refractoriness caused by HLA-I incompatibility. Here, we developed human induced pluripotent cell-derived HLA-I-deficient platelets (HLA-KO iPLA...

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Detalles Bibliográficos
Autores principales: Suzuki, Daisuke, Flahou, Charlotte, Yoshikawa, Norihide, Stirblyte, Ieva, Hayashi, Yoshikazu, Sawaguchi, Akira, Akasaka, Marina, Nakamura, Sou, Higashi, Natsumi, Xu, Huaigeng, Matsumoto, Takuya, Fujio, Kosuke, Manz, Markus G., Hotta, Akitsu, Takizawa, Hitoshi, Eto, Koji, Sugimoto, Naoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962657/
https://www.ncbi.nlm.nih.gov/pubmed/31883921
http://dx.doi.org/10.1016/j.stemcr.2019.11.011

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