Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements

In mammals, LINE-1 (L1) retrotransposons constitute between 15% and 20% of the genome. Although only a few copies have retained the ability to retrotranspose, evidence in brain and differentiating pluripotent cells indicates that L1 retrotransposition occurs and creates mosaics in normal somatic tis...

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Detalles Bibliográficos
Autores principales: Della Valle, Francesco, Thimma, Manjula P., Caiazzo, Massimiliano, Pulcrano, Salvatore, Celii, Mirko, Adroub, Sabir A., Liu, Peng, Alanis-Lobato, Gregorio, Broccoli, Vania, Orlando, Valerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962658/
https://www.ncbi.nlm.nih.gov/pubmed/31902705
http://dx.doi.org/10.1016/j.stemcr.2019.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962658/
https://www.ncbi.nlm.nih.gov/pubmed/31902705
http://dx.doi.org/10.1016/j.stemcr.2019.12.002

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